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HYDROmorphone HCl ER
Hydromorphone HCl ER (extended release) is a potent opioid analgesic used for the management of severe pain that requires continuous, around-the-clock opioid administration. It is formulated to release hydromorphone over an extended period, providing prolonged pain relief for patients with chronic pain conditions.
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Frequently Asked Questions
How quickly does Hydromorphone HCl ER provide pain relief?
The onset of pain relief may take several hours, and the extended-release formulation is designed to provide relief over 24 hours.
Can I take Hydromorphone HCl ER while pregnant?
Consult your healthcare provider for guidance, as the use during pregnancy should be evaluated based on risks and benefits.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up.
Are there any specific storage instructions for Hydromorphone HCl ER?
Store at room temperature, away from moisture and light. Keep out of reach of children.
Is Hydromorphone HCl ER safe for long-term use?
Long-term use should be monitored by a healthcare provider to manage risks, including dependence and potential adverse effects.
Comprehensive Drug Guide
How Does HYDROmorphone HCl ER Work?
Hydromorphone works by binding to opioid receptors in the central nervous system, particularly the mu-opioid receptors. This action alters the perception of pain and emotional response to pain, leading to effective pain relief. The extended-release formulation allows for sustained analgesic effects over a longer duration.
Common Dosages
- Extended-release tablets: Common strengths include 8 mg, 12 mg, 16 mg, 24 mg, 32 mg, and 64 mg.
Typical Dosing
The typical dosing for Hydromorphone HCl ER is:
- For Chronic Pain Management: The initial dose is usually determined based on previous opioid use, but the starting dose for opioid-naive patients typically begins at 8 mg taken orally every 24 hours. Doses may be adjusted based on the patient's response and tolerance.
Typical Dosing
FDA Approved Indications
- Management of severe pain that requires continuous, long-term opioid therapy.
Who Shouldn't Take HYDROmorphone HCl ER?
- Hypersensitivity: Known hypersensitivity to hydromorphone or any components of the formulation.
- Severe Respiratory Depression: Should not be used in patients with significant respiratory issues or acute asthma attacks.
- History of Substance Abuse: Use with caution in patients with a history of substance use disorder.
Advice From The Pharmacist
- How to Use: Take hydromorphone ER exactly as prescribed. Swallow the tablet whole; do not crush, chew, or break it, as this may lead to rapid release and increased risk of overdose.
- Monitor for Side Effects: Patients should be monitored for signs of respiratory depression, sedation, and potential allergic reactions.
- Avoid Alcohol: Alcohol can increase the risk of serious side effects and should be avoided while taking this medication.
Side Effects of HYDROmorphone HCl ER
Common Side Effects
- Drowsiness
- Dizziness
- Constipation
- Nausea
Uncommon/Severe Side Effects
- Respiratory depression: Symptoms like slow or difficult breathing.
- Severe allergic reactions: Such as rash, itching, or difficulty breathing.
Risks and Warnings of HYDROmorphone HCl ER
- Caution with Other CNS Depressants: Concurrent use with other central nervous system depressants may enhance sedation and respiratory depression.
- Dependence and Withdrawal: Long-term use can lead to physical dependence and withdrawal symptoms upon discontinuation.
Interactions with HYDROmorphone HCl ER
Common Drug Interactions
- Drug Interactions: Hydromorphone HCl ER may interact with other medications that affect the central nervous system, including sedatives, other opioids, and certain antidepressants. Always inform your healthcare provider about all medications you are taking.
Alternatives to HYDROmorphone HCl ER
- Other Opioid Analgesics: Such as morphine or oxycodone for moderate to severe pain management.
- Non-Opioid Pain Relievers: Such as acetaminophen or NSAIDs for less severe pain.
