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Horizant
Horizant is the brand name for gabapentin enacarbil, a prodrug of gabapentin. It is primarily used for the treatment of moderate to severe primary restless legs syndrome (RLS) and for the management of postherpetic neuralgia in adults. Horizant helps alleviate symptoms of these conditions by modulating the release of neurotransmitters in the brain, thereby reducing pain and discomfort.
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Frequently Asked Questions
How quickly does Horizant work?
Patients may start to notice improvements in restless legs syndrome symptoms within a few days to weeks of starting treatment.
Can I take Horizant with other medications?
Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs, to avoid potential interactions.
What should I do if I miss a dose of Horizant?
If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Horizant safe during pregnancy?
The safety of Horizant during pregnancy has not been fully established. Discuss with your healthcare provider if you are pregnant or planning to become pregnant.
Can I stop taking Horizant if I feel better?
It is important to continue taking Horizant for the full duration prescribed, even if you feel better. Consult your healthcare provider before making any changes to your treatment plan.
Comprehensive Drug Guide
How Does Horizant Work?
Gabapentin enacarbil is converted to gabapentin in the body. Gabapentin works by inhibiting the release of excitatory neurotransmitters, which are responsible for transmitting pain signals in the nervous system. This action helps to relieve pain associated with conditions like postherpetic neuralgia and reduces the discomfort caused by restless legs syndrome.
Common Dosages
- For restless legs syndrome: The recommended dose is 600 mg taken orally once daily in the evening, usually about 2 to 3 hours before bedtime.
- For postherpetic neuralgia: The recommended starting dose is 600 mg taken orally once daily in the evening.
Typical Dosing
- For restless legs syndrome: Take 600 mg once daily in the evening.
- For postherpetic neuralgia: Begin with 600 mg once daily in the evening. Dosage may be adjusted based on clinical response.
Typical Dosing
FDA Approved Indications
- Treatment of moderate to severe primary restless legs syndrome (RLS)
- Management of postherpetic neuralgia in adults.
Who Shouldn't Take Horizant?
- Known hypersensitivity to gabapentin, gabapentin enacarbil, or any components of the formulation.
- Severe renal impairment: Caution is advised, and dosage adjustments may be necessary.
Advice From The Pharmacist
- Use as prescribed: Follow your healthcare provider's instructions regarding dosage and timing for optimal results. Do not stop taking Horizant without consulting your provider.
- Monitor for side effects: Common side effects may include dizziness, fatigue, drowsiness, and nausea. Report any severe or unusual symptoms to your healthcare provider.
- Avoid abrupt discontinuation: Stopping Horizant suddenly can lead to withdrawal symptoms. If discontinuation is necessary, your healthcare provider will provide a tapering schedule.
- Store Horizant at room temperature, away from moisture and heat, and keep it out of reach of children.
Side Effects of Horizant
Common Side Effects
- Dizziness
- Drowsiness or fatigue
- Nausea
- Vomiting
- Dry mouth
Uncommon/Severe Side Effects
- Severe allergic reactions (e.g., rash, itching, swelling, difficulty breathing)
- Mood changes: Such as depression, anxiety, or suicidal thoughts.
Risks and Warnings of Horizant
- Drowsiness: Horizant may cause significant drowsiness or dizziness. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
- Risk of abuse: Although not classified as a controlled substance, gabapentin has potential for misuse and should be monitored accordingly.
- Neuropsychiatric Effects: Patients with a history of mood disorders should be monitored for any changes in behavior or mood.
Interactions with Horizant
Common Drug Interactions
- CNS depressants: The sedative effects may be enhanced when taken with other central nervous system depressants, such as alcohol, benzodiazepines, or opioids.
- Antacids: Antacids containing aluminum or magnesium may decrease the absorption of Horizant, so it’s advisable to take them at least 2 hours apart.
Alternatives to Horizant
- Other medications for restless legs syndrome: Such as ropinirole or pramipexole, which are dopamine agonists.
- Other treatments for postherpetic neuralgia: Such as pregabalin or tricyclic antidepressants.
