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Hetlioz
Hetlioz (generic name: tasimelteon) is a medication primarily used for the treatment of non-24-hour sleep-wake disorder (non-24), particularly in individuals who are totally blind. It is a melatonin receptor agonist that helps regulate the body’s circadian rhythm, promoting a more natural sleep cycle. By mimicking the action of melatonin, Hetlioz assists individuals in falling asleep and staying asleep, thereby improving overall sleep quality.
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Frequently Asked Questions
How long does it take for Hetlioz to work?
Patients may start to experience benefits within a few days, but it may take a few weeks for optimal results.
Can Hetlioz be taken during pregnancy?
Hetlioz should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider for personalized advice.
What should I do if I miss a dose of Hetlioz?
If you miss a dose, skip it and take the next dose at the regular scheduled time. Do not double up on doses.
Are there any dietary restrictions while taking Hetlioz?
There are no specific dietary restrictions, but it is advisable to avoid alcohol while taking the medication.
Is Hetlioz safe for long-term use?
Hetlioz can be used safely under the supervision of a healthcare provider, with regular monitoring for potential side effects and effectiveness in managing sleep-wake disorders.
Comprehensive Drug Guide
How Does Hetlioz Work?
- Binding to melatonin receptors: Tasimelteon selectively binds to the MT1 and MT2 melatonin receptors in the brain, which are involved in the regulation of the sleep-wake cycle.
- Regulating circadian rhythms: By activating these receptors, Hetlioz helps synchronize the internal body clock to promote natural sleep patterns.
Common Dosages
- Tasimelteon: 20 mg capsules, taken once daily at bedtime.
Typical Dosing
- For non-24-hour sleep-wake disorder: The recommended dose is 20 mg taken orally 30 minutes before bedtime.
Typical Dosing
FDA Approved Indications
- Treatment of non-24-hour sleep-wake disorder in adults who are blind.
Who Shouldn't Take Hetlioz?
- Known hypersensitivity to tasimelteon or any components of the formulation.
- Severe hepatic impairment, as this may affect the metabolism of the drug.
Advice From The Pharmacist
- Take Hetlioz 30 minutes before bedtime for optimal effectiveness.
- Consistency is key; try to take it at the same time every night to help regulate your sleep-wake cycle.
- Avoid alcohol and other sedatives while taking Hetlioz, as these may increase drowsiness or affect the medication's efficacy.
- Monitor for any unusual side effects, such as changes in mood or behavior, and report them to your healthcare provider.
Side Effects of Hetlioz
Common Side Effects
- Drowsiness
- Headache
- Fatigue
- Nausea
- Vivid dreams
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling, or difficulty breathing)
- Mood changes (depression or anxiety)
Risks and Warnings of Hetlioz
- Daytime Drowsiness: Hetlioz may cause drowsiness the next day; caution is advised when driving or operating heavy machinery after taking the medication.
- Caution in Liver Disease: Patients with liver issues should be monitored closely, as the drug may accumulate in the body.
- Not Recommended for Use in Sighted Individuals: Hetlioz is specifically indicated for individuals who are blind and experience non-24-hour sleep-wake disorder.
Interactions with Hetlioz
Common Drug Interactions
- CYP450 1A2 Inhibitors: Medications that inhibit this enzyme may increase the levels of Hetlioz in the body, enhancing its effects and side effects.
- Other Sedatives: Caution should be taken when using Hetlioz with other sedatives, as the combined effects may lead to increased sedation.
Alternatives to Hetlioz
- Melatonin supplements: May help some individuals with sleep-wake disorders.
- Other sleep medications: Such as zolpidem or eszopiclone, which can be considered for short-term sleep issues.
- Cognitive Behavioral Therapy for Insomnia (CBT-I): Non-pharmacological approaches to managing sleep disturbances.
