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Hemangeol
Hemangeol (generic name: propranolol hydrochloride) is a medication primarily used for the treatment of hemangiomas, particularly in infants and young children. Hemangiomas are benign tumors made up of blood vessels that typically appear in the early months of life. Hemangeol is classified as a beta-blocker, and it works by decreasing blood flow to the tumor, reducing its size and associated symptoms.
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Frequently Asked Questions
How long does it take for Hemangeol to work?
Improvements in the size of the hemangioma may be observed within several weeks of starting treatment, with maximum effects often seen after several months.
Can Hemangeol be taken during pregnancy?
Hemangeol should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider for personalized advice.
What should I do if I miss a dose of Hemangeol?
If you miss a dose, administer it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any special storage requirements for Hemangeol?
Store Hemangeol at room temperature, away from moisture and heat. Keep the container tightly closed when not in use.
Is Hemangeol safe for long-term use?
Hemangeol can be safe for long-term use under the supervision of a healthcare provider, with regular monitoring for potential side effects and effectiveness in treating hemangiomas.
Comprehensive Drug Guide
How Does Hemangeol Work?
- Blocking beta-adrenergic receptors: Propranolol inhibits the action of epinephrine and norepinephrine on beta receptors, leading to reduced blood vessel growth and stabilization of hemangiomas.
- Decreasing blood flow: By lowering blood pressure and reducing blood flow to the hemangioma, it helps shrink the size of the tumor over time.
Common Dosages
- Propranolol: Starting at 0.15 mg/kg given orally twice daily. The dosage may be gradually increased based on clinical response and tolerability.
Typical Dosing
- For infantile hemangiomas: The recommended starting dose is 0.15 mg/kg twice daily. Depending on the patient's response, the dose can be increased to a maximum of 0.5 mg/kg twice daily.
Typical Dosing
FDA Approved Indications
- Treatment of proliferating infantile hemangiomas that require intervention based on location, size, or complications.
Who Shouldn't Take Hemangeol?
- Known hypersensitivity to propranolol or any components of the formulation.
- Severe asthma or other significant respiratory conditions, as beta-blockers may exacerbate bronchospasm.
- Bradycardia (slow heart rate) or severe heart block without a functioning pacemaker.
Advice From The Pharmacist
- Administer Hemangeol with or without food, but maintain consistent dosing with respect to meals.
- Monitor the child for side effects, especially during the initial treatment phase, including changes in heart rate, blood pressure, and respiratory function.
- Avoid abrupt discontinuation of the medication to prevent withdrawal symptoms; tapering may be necessary.
Side Effects of Hemangeol
Common Side Effects
- Fatigue
- Cold extremities
- Hypotension (low blood pressure)
- Bradycardia (slow heart rate)
Uncommon/Severe Side Effects
- Respiratory issues (wheezing or difficulty breathing)
- Severe allergic reactions (such as rash, itching, swelling, or difficulty breathing)
Risks and Warnings of Hemangeol
- Cardiovascular Monitoring: Regular monitoring of heart rate and blood pressure is crucial, especially in infants and children.
- Respiratory Caution: Use with caution in patients with a history of respiratory issues, as beta-blockers can cause bronchoconstriction.
- Blood Sugar Levels: Propranolol can mask symptoms of hypoglycemia; monitoring is especially important in diabetic patients.
Interactions with Hemangeol
Common Drug Interactions
- Other antihypertensive agents: Concurrent use may enhance the blood pressure-lowering effects of Hemangeol.
- Calcium channel blockers: May lead to excessive bradycardia or hypotension when combined with Hemangeol.
- Antiarrhythmic drugs: Caution is advised when used with other medications that affect heart rate.
Alternatives to Hemangeol
- Laser therapy: Often considered for the treatment of hemangiomas if they do not respond adequately to pharmacologic therapy.
- Corticosteroids: Systemic or topical corticosteroids may be used for treating some cases of hemangiomas.
