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Hemady
Hemady, also known as Gemtuzumab Ozogamicin, is an antineoplastic medication used to treat patients with acute myeloid leukemia (AML). It functions by binding to CD33, a protein commonly found on the surface of AML cells, delivering a toxic dose directly to the cancer cells. Some common side effects include fever, nausea, and low blood cell count, your doctor, however, will weigh these side effects against the potential benefits of the treatment.
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Frequently Asked Questions
Can I eat grapefruit while taking Hemady?
No, grapefruit juice is known to interact with Hemady and may enhance its side effects.
I am pregnant. Can I take Hemady?
Generally, Hemady should be avoided during pregnancy as it can harm the fetus. Always consult with your healthcare provider in such instances.
What should I do if I miss a dose of Hemady?
Treatment with Hemady is done under medical supervision. Therefore, if a dose is missed, it will be taken care of by your healthcare provider.
Comprehensive Drug Guide
How Does Hemady Work?
Hemady is an antiCD33 directed antibodydrug conjugate or immunoconjugate, which targets cancer cells via monoclonal antibodies linked to an anticancer drug.
What is Hemady Used For?
FDA Indications: Hemady is primarily indicated for relapsed or refractory CD33positive AML patients. It can also be utilized as part of the initial treatment in certain older AML patients.
Offlabel uses: There are currently no recognized offlabel uses for Hemady.
Common Dosages
Injection: 4.5 mg
Typical Dosing
FDA Approved Indications
- 3 mg/m2 for the first course of treatment, and 2 mg/m2 for subsequent courses.
- Doses are typically administered on days 1, 4, and 7 of a treatment cycle.
Who Shouldn't Take Hemady?
- Individuals with hypersensitivity to Hemady or its ingredients.
- Individuals with significant liver disease.
- Pregnant or breastfeeding women (unless prescribed by your doctor).
Advice From The Pharmacist
- Hemady administration should be done by a healthcare professional.
- Keep all your doctor's appointments, and don't hesitate to communicate to them any new symptoms.
- Report any signs or symptoms of infection such as fever, chills, or sore throat.
- Hydration is essential as Hemady can affect your kidneys.
- Avoid cuts, bruises, and injuries as Hemady can decrease your body's ability to clot.
Side Effects of Hemady
Common Side Effects
- Fever is common during treatment.
- Hemady can cause various gastrointestinal problems like nausea, vomiting, constipation, or diarrhea.
- You may feel fatigued or weak.
Uncommon/Severe Side Effects
- Uncommon Side Effects:
- Hemady may cause lowered blood cell counts leading to anemia, reduced ability to fight infections, or increased bleeding.
- It may affect your liver causing jaundice, dark urine, or itching.
- Rare Side Effects:
- Hemady occasionally causes infusionrelated reactions which can include symptoms like fever, chills, rash, or breathing difficulties.
- Severe Side Effects:
- It may affect your heart and cause symptoms like chest pain, breathlessness, or swelling in your legs.
Risks and Warnings of Hemady
- Be cautious with hematological toxicity: Hemady can induce severe or even lifethreatening thrombocytopenia, neutropenia, or anemia.
- Individuals with hepatic impairment need to proceed with caution.
- Hemady may produce infusion reactions which can be severe, so prompt action should be taken if you experience any distressing symptoms.
- Pregnancy: Hemady can harm the fetus and should generally be avoided during pregnancy.
Interactions with Hemady
Common Drug Interactions
- Other chemotherapeutics
- Live vaccines
- Certain antibiotics
Alternatives to Hemady
- Mylotarg
- Cytarabine
- Azacitidine
- Daunorubicin
- Hydroxyurea
- Midostaurin
