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Hemabate
Hemabate is the brand name for carboprost tromethamine, a synthetic prostaglandin used primarily in obstetrics to induce uterine contractions. It is indicated for the treatment of postpartum hemorrhage (excessive bleeding after childbirth) due to uterine atony (lack of muscle tone). Hemabate helps to stimulate contractions of the uterus, thereby reducing blood loss and aiding in the delivery of the placenta.
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Frequently Asked Questions
How quickly does Hemabate work?
Hemabate typically begins to take effect within 15 to 30 minutes of administration, leading to increased uterine contractions and decreased bleeding.
Can Hemabate be used in all patients with postpartum hemorrhage?
Hemabate is indicated for postpartum hemorrhage due to uterine atony, particularly when other treatments are ineffective. However, caution is needed in patients with certain contraindications, such as asthma.
What should I do if I experience side effects after receiving Hemabate?
If you experience severe side effects, such as difficulty breathing or severe abdominal pain, seek medical attention immediately.
Is Hemabate safe during breastfeeding?
Hemabate is generally considered safe during breastfeeding, but it is advisable to consult your healthcare provider regarding any concerns or specific circumstances.
Can I stop treatment with Hemabate once my bleeding improves?
It is important to follow your healthcare provider's instructions and complete the treatment course as prescribed, even if symptoms improve, to ensure proper management of postpartum hemorrhage.
Comprehensive Drug Guide
How Does Hemabate Work?
Carboprost tromethamine works by stimulating specific prostaglandin receptors in the uterus, leading to increased contractions. This action helps the uterus contract effectively, facilitating the expulsion of retained placental tissue and reducing uterine bleeding. The increased contraction of the smooth muscle also helps to constrict blood vessels, which further aids in controlling hemorrhage.
Common Dosages
- 250 mcg (0.25 mg) administered intramuscularly. This may be repeated every 15 to 90 minutes as needed, with a maximum total dose of 2 mg (8 doses).
Typical Dosing
- For postpartum hemorrhage: Administer 250 mcg IM, which can be repeated every 15 to 90 minutes if necessary, up to a total of 2 mg.
Typical Dosing
FDA Approved Indications
- Treatment of postpartum hemorrhage due to uterine atony that is unresponsive to conventional treatment.
Who Shouldn't Take Hemabate?
- Known hypersensitivity to carboprost or any components of the formulation.
- Active cardiovascular disease, especially conditions that may be exacerbated by increased uterine tone.
- Pelvic inflammatory disease or active infections that may worsen with uterine contractions.
- Asthma: Caution is advised due to the potential for bronchospasm.
Advice From The Pharmacist
- Use as prescribed: Follow your healthcare provider's instructions regarding dosing and administration. Monitor the patient closely for response to treatment.
- Monitor for side effects: Common side effects may include nausea, vomiting, diarrhea, fever, and headache. Report any severe or unusual symptoms to your healthcare provider.
- Prepare for potential adverse reactions: Ensure the presence of appropriate medical support to manage any potential bronchospasm or cardiovascular complications during administration.
- Store Hemabate at room temperature, away from light, and keep it out of reach of children.
Side Effects of Hemabate
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Fever
- Headache
Uncommon/Severe Side Effects
- Severe allergic reactions (e.g., rash, itching, swelling, difficulty breathing)
- Bronchospasm, particularly in patients with a history of asthma or respiratory issues.
Risks and Warnings of Hemabate
- Bronchospasm: Patients with asthma or a history of respiratory conditions should be closely monitored during treatment, as carboprost may induce bronchospasm.
- Cardiovascular Effects: Caution is necessary in patients with cardiovascular disease, as increased uterine tone may affect hemodynamics.
- Uterine Rupture: There is a risk of uterine rupture if the drug is used in patients with a history of uterine surgery or cesarean deliveries.
Interactions with Hemabate
Common Drug Interactions
- Oxytocin: The concurrent use of other uterotonics should be approached with caution, as the combined effect may lead to excessive uterine contractions.
Alternatives to Hemabate
- Other uterotonics: Such as oxytocin or methylergometrine (Methergine) can also be used for managing postpartum hemorrhage due to uterine atony.
- Surgical interventions: In cases of severe hemorrhage that do not respond to medical therapy, surgical options may be considered.
