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Glyxambi
Glyxambi is a combination medication that contains empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, and linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor. It is used to improve glycemic control in adults with type 2 diabetes mellitus. Glyxambi works by targeting different mechanisms to help lower blood sugar levels, making it an effective option for individuals who require more than one medication to manage their diabetes.
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Frequently Asked Questions
How quickly does Glyxambi work?
Patients may start to see improvements in blood glucose levels within a few weeks of starting Glyxambi, although individual responses may vary.
Can I take Glyxambi with other diabetes medications?
Yes, Glyxambi can be used in combination with other diabetes medications, but inform your healthcare provider about all medications you are taking to ensure safe use.
What should I do if I miss a dose of Glyxambi?
If you miss a dose, take it as soon as you remember on the same day. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Glyxambi safe during pregnancy?
The safety of Glyxambi during pregnancy has not been established. Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
Can I stop taking Glyxambi if my blood sugar levels improve?
It is important to continue taking Glyxambi as prescribed to maintain blood sugar control. Consult your healthcare provider before making any changes to your treatment plan.
Comprehensive Drug Guide
How Does Glyxambi Work?
Empagliflozin works by preventing the reabsorption of glucose in the kidneys, allowing excess glucose to be excreted in the urine, which helps lower blood glucose levels. Linagliptin enhances the levels of incretin hormones, which help to regulate blood sugar by increasing insulin secretion in response to meals and decreasing glucagon secretion from the pancreas. The combination of these two actions leads to improved glycemic control.
What is Glyxambi Used For?
Common Dosages
- 1 tablet taken orally once daily, with or without food. The usual strength is 10 mg of empagliflozin and 5 mg of linagliptin.
Typical Dosing
- For type 2 diabetes management: Take 1 tablet (10 mg empagliflozin and 5 mg linagliptin) once daily.
Typical Dosing
FDA Approved Indications
- Improvement of glycemic control in adults with type 2 diabetes mellitus, as an adjunct to diet and exercise.
Who Shouldn't Take Glyxambi?
- Known hypersensitivity to empagliflozin, linagliptin, or any components of the formulation.
- Severe renal impairment (eGFR < 30 mL/min) or end-stage renal disease.
- Diabetic ketoacidosis.
Advice From The Pharmacist
- Use as prescribed: Take Glyxambi exactly as directed by your healthcare provider. Consistency in taking the medication can help optimize its effectiveness.
- Monitor for side effects: Common side effects may include urinary tract infections, genital mycotic infections, and gastrointestinal symptoms. Report any severe or unusual symptoms to your healthcare provider.
- Stay hydrated: Ensure adequate fluid intake to reduce the risk of dehydration, especially if experiencing increased urination.
- Store Glyxambi at room temperature, away from moisture and heat, and keep it out of reach of children.
Side Effects of Glyxambi
Common Side Effects
- Urinary tract infections
- Genital yeast infections
- Nausea
- Diarrhea
- Headache
Uncommon/Severe Side Effects
- Pancreatitis: Symptoms may include severe abdominal pain that does not go away.
- Kidney problems: May occur, especially in patients with existing kidney issues.
Risks and Warnings of Glyxambi
- Risk of ketoacidosis: Patients should be informed about the signs and symptoms of ketoacidosis, a serious condition that can occur even when blood sugar levels are not extremely high.
- Renal Function Monitoring: Regular monitoring of kidney function is essential, particularly in patients with preexisting renal impairment.
- Risk of dehydration: Due to increased urination, patients should be advised to maintain hydration and recognize signs of dehydration.
Interactions with Glyxambi
Common Drug Interactions
- Diuretics: May increase the risk of dehydration and hypotension.
- Insulin or insulin secretagogues: May increase the risk of hypoglycemia; dosage adjustments may be necessary.
Alternatives to Glyxambi
- Other oral antidiabetic medications: Such as metformin, sulfonylureas, or other SGLT2 inhibitors and DPP-4 inhibitors.
- Insulin therapy: May be considered for patients with more advanced diabetes or those not achieving adequate control with oral medications.
