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Fuzeon
Fuzeon (enfuvirtide) is an antiretroviral medication used for the treatment of HIV-1 infection in adults and pediatric patients. It is classified as a fusion inhibitor, which means it works by preventing the virus from entering and infecting healthy CD4 cells. Fuzeon is typically used in combination with other antiretroviral agents for patients who have experienced treatment failure with other therapies.
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Frequently Asked Questions
How is Fuzeon administered?
Fuzeon is administered as a subcutaneous injection, typically in the thigh, abdomen, or upper arm.
Can I use Fuzeon alone for HIV treatment?
Fuzeon should not be used alone; it must be combined with other antiretroviral medications for effective treatment.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses.
Are there any special storage instructions for Fuzeon?
Store Fuzeon at room temperature. After reconstitution, it should be used within 24 hours if stored at room temperature or within 48 hours if refrigerated.
What are the common side effects of Fuzeon?
Common side effects include injection site reactions, nausea, fatigue, and diarrhea. Contact your healthcare provider if you experience severe or persistent side effects.
Comprehensive Drug Guide
How Does Fuzeon Work?
Fuzeon works by binding to the gp41 subunit of the HIV envelope glycoprotein. This binding inhibits the fusion of the viral membrane with the host cell membrane, preventing the virus from entering the CD4 cells. By blocking this critical step in the viral life cycle, Fuzeon helps reduce the viral load and protects the immune system.
Common Dosages
Fuzeon is available in the following form:
- Lyophilized powder for injection: 90 mg per vial.
Typical Dosing
The typical dosing for Fuzeon is:
- For HIV-1 Infection: The recommended dose is 90 mg administered subcutaneously twice daily, in combination with other antiretroviral medications.
Typical Dosing
FDA Approved Indications
Treatment of HIV-1 infection in combination with other antiretroviral agents in adults and pediatric patients.
Who Shouldn't Take Fuzeon?
- Hypersensitivity: Known hypersensitivity to enfuvirtide or any of its components.
- Severe Allergic Reactions: Patients with a history of severe allergic reactions to the medication.
Advice From The Pharmacist
- Administration: Fuzeon is given as a subcutaneous injection. Rotate injection sites to minimize local reactions and discomfort.
- Preparation: Reconstitute the powder with the provided sterile water for injection and gently swirl to dissolve. Do not shake.
- Monitor for Reactions: Watch for local injection site reactions, including pain, swelling, and redness. Report any unusual symptoms to your healthcare provider.
Side Effects of Fuzeon
Common Side Effects
- Injection site reactions: Pain, redness, swelling, or itching.
- Nausea
- Fatigue
- Diarrhea
Uncommon/Severe Side Effects
- Hypersensitivity reactions: Such as rash, fever, and difficulty breathing.
- Increased risk of infections: Due to immune system suppression.
Risks and Warnings of Fuzeon
- Infection Risk: Fuzeon may increase the risk of infections; monitor for signs of new infections.
- Injection Site Reactions: Local reactions at the injection site are common; proper administration techniques can help minimize these.
- Resistance Development: Use in combination with other antiretroviral medications to reduce the risk of developing drug resistance.
Interactions with Fuzeon
Common Drug Interactions
- Drug Interactions: Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements, as interactions may occur.
- Other Antiretrovirals: Use with caution when combined with other antiretroviral therapies, as the regimen should be carefully managed.
Alternatives to Fuzeon
- Other Classes of Antiretrovirals: Such as integrase inhibitors (e.g., raltegravir), protease inhibitors (e.g., darunavir), and NNRTIs (e.g., efavirenz).
- Combination Therapies: Fixed-dose combinations that simplify dosing regimens for patients.
