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Fosamax Plus D
Fosamax Plus D is a combination medication used to treat and prevent osteoporosis in postmenopausal women and men. It combines alendronate sodium, a bisphosphonate, and vitamin D3. Alendronate works by slowing down the process of bone breakdown, while vitamin D3 helps improve calcium absorption, which is essential for bone health. This combination helps to strengthen bones and reduce the risk of fractures.
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Frequently Asked Questions
How should I take Fosamax Plus D?
Take one tablet once a week with a full glass of water, at least 30 minutes before the first food, drink, or medication of the day. Remain upright for at least 30 minutes after taking the tablet.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember, but do not take two doses in the same week. Resume your regular schedule on the next scheduled day.
Are there any foods or drinks I should avoid?
Avoid taking Fosamax Plus D with food, beverages other than water, or other medications. It should be taken on an empty stomach.
How long should I use Fosamax Plus D?
The duration of treatment depends on your condition and response to the medication. Follow your healthcare provider's instructions and have regular check-ups to assess the need for continued treatment.
Can I take Fosamax Plus D if I have kidney problems?
Fosamax Plus D should be used with caution in patients with renal impairment. Consult your healthcare provider to determine if this medication is appropriate for you.
Comprehensive Drug Guide
How Does Fosamax Plus D Work?
- Alendronate inhibits osteoclast-mediated bone resorption by binding to bone surfaces and interfering with the activity of osteoclasts, the cells responsible for bone breakdown.
- Vitamin D3 enhances intestinal absorption of calcium, which is crucial for bone mineralization and maintenance. Together, these components help to reduce bone loss and increase bone density.
Common Dosages
- Oral tablets: 70 mg of alendronate sodium and 2800 IU or 5600 IU of vitamin D3
Typical Dosing
The typical dosing for Fosamax Plus D is:
- For Osteoporosis Treatment and Prevention: One 70 mg/2800 IU or 5600 IU tablet taken orally once weekly, with a full glass of water, at least 30 minutes before the first food, drink, or medication of the day.
Typical Dosing
FDA Approved Indications
- Treatment and prevention of osteoporosis in postmenopausal women and men.
- Treatment of osteoporosis associated with steroid use in men and women.
Who Shouldn't Take Fosamax Plus D?
- Esophageal Disorders: Patients with abnormalities of the esophagus which delay esophageal emptying.
- Hypocalcemia: Patients with low blood calcium levels.
- Renal Impairment: Severe renal impairment (creatinine clearance less than 35 mL/min).
- Hypersensitivity: Patients with a known hypersensitivity to alendronate, vitamin D3, or any of the product's components.
Side Effects of Fosamax Plus D
Common Side Effects
- Gastrointestinal issues: Abdominal pain, nausea, dyspepsia.
- Musculoskeletal pain: Joint or muscle pain.
- Other: Headache, dizziness, rash.
Uncommon/Severe Side Effects
- Esophageal irritation: Esophageal ulceration or erosion.
- Hypocalcemia: Severe low blood calcium levels.
- Osteonecrosis of the jaw: Particularly in patients with dental problems.
Risks and Warnings of Fosamax Plus D
- Risk of Esophageal Damage: Risk of esophageal ulcers or inflammation; avoid in patients who cannot remain upright for at least 30 minutes after taking the medication.
- Renal Issues: Monitor renal function periodically.
- Bone Pain: May experience severe bone, joint, or muscle pain.
Interactions with Fosamax Plus D
Common Drug Interactions
- Other Medications: Avoid taking Fosamax Plus D with other medications that affect calcium levels or bone metabolism without medical advice.
- Foods and Drinks: Do not take with food, drinks other than water, or other medications.
- Calcium Supplements: Use cautiously with calcium supplements; monitor calcium levels.
Alternatives to Fosamax Plus D
- Other Bisphosphonates: Actonel (risedronate), Boniva (ibandronate).
- Other Osteoporosis Medications: Reclast (zoledronic acid), Prolia (denosumab).
- Calcium and Vitamin D Supplements: Separate calcium and vitamin D supplements if Fosamax Plus D is not suitable.
