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Fondaparinux Sodium
Fondaparinux Sodium is an anticoagulant used to prevent and treat various types of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism (PE). It is a synthetic pentasaccharide that specifically inhibits factor Xa, a crucial enzyme in the blood clotting process. By preventing the formation of clots, Fondaparinux helps reduce the risk of complications associated with blood clots, such as stroke and heart attack.
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Frequently Asked Questions
How should I store Fondaparinux Sodium?
Store it in the refrigerator between 36°F and 46°F (2°C and 8°C). Do not freeze. Keep it away from light and heat.
What should I do if I miss a dose?
Take the missed dose as soon as you remember it, but skip it if it's almost time for your next dose. Do not double up on doses.
Can I stop taking Fondaparinux Sodium on my own?
No, do not stop taking the medication without consulting your healthcare provider, as it could increase your risk of blood clots.
What should I do if I experience side effects?
Contact your healthcare provider immediately if you experience severe side effects or symptoms of bleeding.
Comprehensive Drug Guide
How Does Fondaparinux Sodium Work?
Fondaparinux Sodium works by selectively inhibiting factor Xa, an essential enzyme in the blood coagulation cascade. This inhibition prevents the conversion of prothrombin to thrombin, thereby stopping the formation of clots. This action helps to prevent the growth of existing clots and the formation of new clots in the blood vessels.
Common Dosages
- 2.5 mg
- 5 mg
- 7.5 mg
- 10 mg
Typical Dosing
The typical dosing for Fondaparinux Sodium depends on the condition being treated:
- For deep vein thrombosis (DVT) and pulmonary embolism (PE): The usual dose is 5 mg once daily for patients weighing less than 50 kg, 7.5 mg once daily for those weighing 50-100 kg, and 10 mg once daily for those weighing over 100 kg.
- For prevention of DVT following orthopedic surgery: The dose is typically 2.5 mg once daily, starting 6-8 hours after surgery.
- For prevention of venous thromboembolism in abdominal surgery: The recommended dose is 2.5 mg once daily, starting 6-8 hours after surgery.
Typical Dosing
FDA Approved Indications
- Deep vein thrombosis (DVT)
- Pulmonary embolism (PE)
- Prevention of deep vein thrombosis following orthopedic surgery, such as hip replacement or knee surgery
- Prevention of venous thromboembolism in patients undergoing abdominal surgery
Who Shouldn't Take Fondaparinux Sodium?
- Severe renal impairment: Patients with a creatinine clearance of less than 30 mL/min.
- Active bleeding: Patients with conditions that increase the risk of bleeding, such as recent surgery, trauma, or bleeding disorders.
- Hypersensitivity: Individuals with a known hypersensitivity to Fondaparinux or any of its components.
Advice From The Pharmacist
- Administration: Use the medication exactly as prescribed, typically via a subcutaneous injection. Rotate injection sites to avoid irritation.
- Interactions: Inform your healthcare provider of all other medications you are taking, including over-the-counter drugs and supplements, as some can interact with Fondaparinux.
- Monitoring: Regular monitoring of kidney function and blood counts may be required.
- Avoiding Injury: Be cautious to avoid activities that increase your risk of bleeding or injury.
- Consulting Healthcare Providers: Contact your healthcare provider immediately if you experience symptoms of bleeding, such as unusual bruising, bleeding gums, or blood in the urine.
Side Effects of Fondaparinux Sodium
Common Side Effects
- Bleeding: This can occur at injection sites or more internally.
- Anemia: Low red blood cell count.
- Injection site reactions: Pain, redness, or swelling.
Uncommon/Severe Side Effects
- Severe bleeding: This can be life-threatening and requires immediate medical attention.
- Allergic reactions: Symptoms may include rash, itching, or difficulty breathing.
Risks and Warnings of Fondaparinux Sodium
- Increased bleeding risk: The primary concern is severe bleeding, particularly in patients with recent surgery, trauma, or bleeding disorders.
- Renal impairment: Use with caution in patients with kidney issues, as the drug is cleared through the kidneys.
- Use during pregnancy: It should be used only if the benefits outweigh the risks, as it may affect the fetus.
Interactions with Fondaparinux Sodium
Common Drug Interactions
- Other anticoagulants: Combining with drugs like warfarin or other blood thinners can increase bleeding risk.
- NSAIDs: Nonsteroidal anti-inflammatory drugs can also elevate bleeding risks.
- Food interactions: There are no significant food interactions, but it’s important to discuss all dietary habits with your healthcare provider.
Alternatives to Fondaparinux Sodium
- Heparin: Another injectable anticoagulant used in similar conditions.
- Enoxaparin (Lovenox): A low molecular weight heparin with a similar mechanism of action.
- Warfarin (Coumadin): An oral anticoagulant used for long-term management of clotting disorders.
