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FluMist Quadrivalent
FluMist Quadrivalent is a live attenuated influenza vaccine (LAIV) administered as a nasal spray to protect against four strains of the influenza virus (two A strains and two B strains). It is an alternative to traditional injectable flu vaccines and is used to prevent seasonal influenza (flu) in healthy individuals. FluMist Quadrivalent is approved for use in children and adults aged 2 to 49 years who are otherwise healthy and not pregnant.
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Frequently Asked Questions
How is FluMist Quadrivalent different from injectable flu vaccines?
FluMist is a live attenuated nasal spray vaccine that contains weakened flu viruses, while injectable flu vaccines contain inactivated viruses. FluMist is administered intranasally, while injectable vaccines are given as an intramuscular shot.
Can FluMist Quadrivalent cause the flu?
No, FluMist contains weakened viruses that are designed to not cause illness in healthy individuals. However, mild flu-like symptoms such as a runny nose or low-grade fever may occur as part of the immune response.
How long does it take for FluMist to provide protection?
It takes about two weeks for FluMist to provide full protection against the flu after administration.
Who should not receive FluMist?
FluMist is not recommended for children under 2 years old, adults 50 and older, individuals with asthma, pregnant women, and those with weakened immune systems.
Is FluMist Quadrivalent effective?
Yes, FluMist is effective at preventing the flu in healthy individuals, but its effectiveness may vary depending on the match between the circulating flu strains and those included in the vaccine each year.
Comprehensive Drug Guide
How Does FluMist Quadrivalent Work?
FluMist Quadrivalent contains live, weakened influenza viruses that stimulate the immune system to produce antibodies. These attenuated viruses are designed to replicate only in the cooler environment of the nose and do not cause disease in healthy individuals. By exposing the body to these weakened viruses, FluMist helps the immune system recognize and fight the actual flu virus if the person is exposed later.
Common Dosages
The standard dosage for FluMist Quadrivalent is:
- 0.2 mL administered as a single intranasal spray, with half the dose (0.1 mL) sprayed into each nostril.
Typical Dosing
- For children and adults aged 2 to 49 years: One 0.2 mL nasal spray annually.
- For children aged 2 to 8 years who are receiving the flu vaccine for the first time, two doses may be required, given at least 4 weeks apart.
Typical Dosing
FDA Approved Indications
Active immunization against influenza in healthy individuals aged 2 to 49 years to help prevent the flu and its complications.
Who Shouldn't Take FluMist Quadrivalent?
- Severe allergic reactions (e.g., anaphylaxis) to any component of the vaccine, including egg proteins.
- Children under 2 years of age.
- Individuals with asthma or wheezing episodes within the past 12 months.
- Immunocompromised individuals or those in close contact with severely immunocompromised people.
- Pregnant women.
- Use of aspirin or aspirin-containing products in children and adolescents due to the risk of Reye’s syndrome.
Advice From The Pharmacist
- FluMist should be administered every year, as the flu virus strains change annually, and the vaccine is updated accordingly.
- Avoid contact with immunocompromised individuals for at least 7 days after receiving FluMist, as the live vaccine can shed for a short period.
- Children under 8 years old who are receiving the flu vaccine for the first time may require a second dose at least 4 weeks later.
- Store the vaccine properly, and make sure it is administered by a healthcare provider familiar with nasal spray vaccines.
Side Effects of FluMist Quadrivalent
Common Side Effects
- Runny nose or nasal congestion
- Sore throat (especially in adults)
- Cough
- Low-grade fever
- Muscle aches
- Headache
Uncommon/Severe Side Effects
- Severe allergic reactions (e.g., difficulty breathing, swelling of the face or throat).
- Wheezing or asthma attacks, especially in young children with a history of asthma.
Risks and Warnings of FluMist Quadrivalent
- Vaccine Shedding: FluMist contains live, weakened viruses that can potentially be shed and transmitted to others for a short time after vaccination. While this is rare, individuals who are in close contact with severely immunocompromised people should avoid receiving FluMist.
- Asthma and Wheezing: Children and adults with asthma or recent wheezing episodes should avoid FluMist, as it may exacerbate respiratory symptoms.
- Immune System Suppression: FluMist is contraindicated in individuals with weakened immune systems or those receiving immunosuppressive therapy.
Interactions with FluMist Quadrivalent
Common Drug Interactions
- Antiviral medications (e.g., oseltamivir, zanamivir): These drugs may reduce the effectiveness of FluMist. It is recommended to avoid antiviral flu medications for at least 48 hours before and after receiving FluMist.
- Other live vaccines: FluMist may be given with other live vaccines, but if not given at the same time, wait at least 4 weeks between live vaccines.
- Aspirin-containing products: Children and adolescents receiving FluMist should avoid using aspirin or aspirin-containing products due to the risk of Reye’s syndrome.
Alternatives to FluMist Quadrivalent
- Fluzone Quadrivalent: An inactivated injectable flu vaccine suitable for individuals of all ages, including those with asthma or weakened immune systems.
- Flublok Quadrivalent: A recombinant flu vaccine that is egg-free and suitable for adults aged 18 and older.
- Fluad Quadrivalent: A high-dose flu vaccine recommended for individuals aged 65 and older to provide enhanced protection.
- Flucelvax Quadrivalent: A cell culture-based flu vaccine, suitable for those with egg allergies.
