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Flublok Quadrivalent
Flublok Quadrivalent is a recombinant influenza vaccine designed to protect against four strains of the influenza virus (two A strains and two B strains). Unlike traditional flu vaccines, which are grown in eggs, Flublok is produced using recombinant DNA technology, making it suitable for individuals with egg allergies. It is approved for use in adults aged 18 years and older and helps prevent the flu and reduce flu-related complications, such as pneumonia and bronchitis.
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Frequently Asked Questions
How is Flublok Quadrivalent different from traditional flu vaccines?
Flublok is made using recombinant technology and does not contain egg proteins, making it a good option for individuals with egg allergies. It also provides protection against four flu strains.
Can Flublok Quadrivalent cause the flu?
No, Flublok does not contain any live or inactivated viruses, so it cannot cause the flu. Mild side effects such as muscle aches or a low-grade fever are normal immune responses.
How long does it take for Flublok to work?
It typically takes about two weeks after receiving the vaccine for the body to build full protection against the flu.
Who should receive Flublok Quadrivalent?
Flublok is recommended for adults aged 18 and older, particularly those with egg allergies or those who prefer an egg-free flu vaccine.
Who should receive Flublok Quadrivalent?
Flublok is recommended for adults aged 18 and older, particularly those with egg allergies or those who prefer an egg-free flu vaccine.
Comprehensive Drug Guide
How Does Flublok Quadrivalent Work?
Flublok Quadrivalent contains recombinant hemagglutinin proteins from four influenza virus strains. Hemagglutinin is a surface protein of the flu virus that triggers an immune response. The vaccine stimulates the immune system to produce antibodies, which help protect against future infection from the included strains of the flu virus. Because it is produced without eggs, it is free from egg proteins and other potential allergens commonly found in traditional flu vaccines.
Common Dosages
The standard dosage for Flublok Quadrivalent is:
- 0.5 mL administered as a single intramuscular injection per flu season.
Typical Dosing
- For adults aged 18 and older: One 0.5 mL intramuscular injection annually. It is typically given in the deltoid muscle (upper arm).
Typical Dosing
FDA Approved Indications
- Active immunization against influenza in adults 18 years of age and older.
- It helps prevent flu-related complications such as respiratory infections and hospitalizations.
Who Shouldn't Take Flublok Quadrivalent?
- Severe allergic reactions (e.g., anaphylaxis) to any component of the vaccine.
- Known hypersensitivity to any recombinant proteins used in the vaccine formulation.
Advice From The Pharmacist
- Get vaccinated every year, as the flu virus strains change annually, and the vaccine is updated to match the current strains.
- Flublok cannot cause the flu, as it does not contain live or inactivated viruses. Some people may experience mild side effects such as soreness or fatigue, but these are normal immune responses.
- If you have had severe allergic reactions to traditional flu vaccines, Flublok may be a suitable alternative since it is egg-free.
- After getting the vaccine, continue taking flu prevention measures such as frequent handwashing and avoiding contact with sick individuals.
Side Effects of Flublok Quadrivalent
Common Side Effects
- Pain, redness, or swelling at the injection site
- Headache
- Fatigue
- Muscle aches
Uncommon/Severe Side Effects
- Severe allergic reactions (e.g., difficulty breathing, swelling of the face or throat).
- Guillain-Barré syndrome (GBS), though the risk is very low.
Risks and Warnings of Flublok Quadrivalent
- Allergic Reactions: Individuals with a history of severe allergic reactions to the vaccine or its components should avoid receiving Flublok Quadrivalent.
- Guillain-Barré Syndrome (GBS): While very rare, there is a potential risk of GBS following flu vaccination. Individuals with a history of GBS should discuss the risks with their healthcare provider.
- Effectiveness: No vaccine provides 100% protection. Flublok significantly reduces the risk of contracting influenza, but individuals should continue flu prevention practices.
Interactions with Flublok Quadrivalent
Common Drug Interactions
Flublok Quadrivalent does not have known significant drug interactions. However, it is important to inform your healthcare provider about any medications or vaccines you are taking. Considerations include:
- Other vaccines: Flublok can be administered alongside other vaccines, but they should be given at different injection sites.
- Immunosuppressive medications: Patients taking immunosuppressive drugs (e.g., corticosteroids, chemotherapy) may have a reduced immune response to the vaccine.
Alternatives to Flublok Quadrivalent
- Flucelvax Quadrivalent: A cell culture-based flu vaccine, free from egg proteins, and suitable for individuals with egg allergies.
- Fluad Quadrivalent: An adjuvanted flu vaccine recommended for adults aged 65 and older to enhance immune response.
- Fluzone High-Dose Quadrivalent: A higher-dose vaccine designed for adults aged 65 and older to provide stronger protection against the flu.
- Standard egg-based flu vaccines: These vaccines may be suitable for individuals without egg allergies.
