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Fluad Quadrivalent

Fluad Quadrivalent is an adjuvanted inactivated influenza vaccine designed to provide protection against four strains of the influenza virus (two A strains and two B strains). It is formulated specifically for adults aged 65 years and older, as this population is at higher risk for complications from the flu. The vaccine contains an adjuvant, which helps to boost the immune response in older adults, making it more effective in this population compared to standard flu vaccines.



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Frequently Asked Questions

How does Fluad Quadrivalent differ from other flu vaccines?
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Fluad Quadrivalent contains an adjuvant that enhances the immune response, making it particularly effective in adults aged 65 and older. This group is at higher risk of severe complications from the flu, and the adjuvant helps the body produce a stronger immune response.

Can Fluad Quadrivalent cause the flu?
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No, Fluad Quadrivalent cannot cause the flu because it contains inactivated (killed) viruses. Some people may experience mild side effects like soreness or low-grade fever, but these are signs of the immune system responding to the vaccine.

Is Fluad Quadrivalent safe for people with egg allergies?
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Individuals with severe egg allergies should consult their healthcare provider before receiving Fluad Quadrivalent, as it is produced using eggs. For those with mild egg allergies, the vaccine may still be administered under medical supervision.

How long does Fluad Quadrivalent last?
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The protection provided by Fluad Quadrivalent typically lasts for one flu season. It is recommended to get the flu vaccine annually, as flu virus strains change from year to year.

What should I do if I have a severe allergic reaction to Fluad Quadrivalent?
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Seek emergency medical attention immediately if you experience symptoms of a severe allergic reaction, such as difficulty breathing, swelling of the face or throat, or hives.

Comprehensive Drug Guide

How Does Fluad Quadrivalent Work?

Fluad Quadrivalent works by introducing inactivated (killed) influenza viruses into the body, which do not cause illness but stimulate the immune system to produce antibodies. These antibodies help protect against future infections from the same strains of the virus. The addition of an adjuvant (MF59) enhances the body’s immune response, making it more effective in generating protection, particularly in older adults who may have weaker immune systems.



Common Dosages

The standard dose of Fluad Quadrivalent is:

  • 0.5 mL administered as a single intramuscular (IM) injection, typically given once per flu season.

Typical Dosing

  • For influenza prevention: One 0.5 mL intramuscular injection annually, usually administered in the upper arm (deltoid muscle). The best time for vaccination is before the flu season starts, typically in the fall, but it can be given at any time during flu season.

Typical Dosing

FDA Approved Indications

Active immunization against influenza in adults 65 years of age and older. It helps reduce the risk of flu-related complications in this high-risk group.

Who Shouldn't Take Fluad Quadrivalent?

  • Severe allergic reactions (e.g., anaphylaxis) to any component of the vaccine, including egg proteins, as the vaccine is produced using eggs.
  • Known hypersensitivity to any of the adjuvants or other ingredients in the vaccine.

Advice From The Pharmacist

  • Fluad Quadrivalent is given once a year and should be administered before the flu season starts. However, it can be given at any time during the season.
  • After receiving the vaccine, some mild side effects like soreness at the injection site, fatigue, or mild fever may occur, but these typically resolve within a few days.
  • The vaccine cannot cause the flu because it contains inactivated (killed) virus.
  • Even if you've had the flu shot in the past, you should get a new one each year, as the flu virus strains change over time, and immunity wanes.
  • If you have an allergy to eggs or a history of severe allergic reactions to the flu vaccine, discuss with your healthcare provider before receiving Fluad Quadrivalent.

Side Effects of Fluad Quadrivalent

Common Side Effects

  • Pain, redness, or swelling at the injection site
  • Muscle aches
  • Headache
  • Fatigue
  • Fever


Uncommon/Severe Side Effects

  • Severe allergic reactions (anaphylaxis), which may cause difficulty breathing, hives, or swelling of the face and throat.
  • Guillain-Barré syndrome (GBS), although the risk is very low.

Risks and Warnings of Fluad Quadrivalent

  • Allergic Reactions: Patients with a history of severe allergic reactions to flu vaccines or any of the components in Fluad Quadrivalent (such as egg proteins) should not receive this vaccine.
  • Guillain-Barré Syndrome (GBS): Although extremely rare, individuals with a history of GBS should discuss the risks and benefits of the vaccine with their healthcare provider.
  • Effectiveness: No vaccine provides 100% protection. Fluad Quadrivalent significantly reduces the risk of flu, but individuals should still take precautions to prevent infection (e.g., hand washing, avoiding contact with sick individuals).

Interactions with Fluad Quadrivalent

Common Drug Interactions

Fluad Quadrivalent does not have known significant drug interactions, but it is important to inform your healthcare provider about any medications or vaccines you are taking. Some considerations include:

  • Other vaccines: Fluad Quadrivalent can be given at the same time as other vaccines, but they should be administered at different injection sites.
  • Immunosuppressive therapies: Individuals on immunosuppressive medications (e.g., corticosteroids, chemotherapy) may have a reduced immune response to the vaccine.

Alternatives to Fluad Quadrivalent

  • Fluzone High-Dose Quadrivalent: Another flu vaccine specifically designed for adults aged 65 and older, containing four times the antigen dose of standard flu vaccines.
  • Fluad Trivalent: A similar vaccine containing three strains (instead of four) for the prevention of flu in older adults.
  • Standard Quadrivalent Flu Vaccines: Non-adjuvanted flu vaccines that protect against the same four strains but may not be as effective in older adults as adjuvanted or high-dose vaccines.