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Flac
Flac (generic name: flutamide) is a nonsteroidal anti-androgen medication used primarily in the treatment of prostate cancer. It works by blocking the effects of androgens (male hormones like testosterone) on the prostate, slowing the growth of cancer cells. Flac is often used in combination with luteinizing hormone-releasing hormone (LHRH) agonists to manage advanced prostate cancer.
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Frequently Asked Questions
How long does it take for Flac to start working?
Flac typically begins working within a few weeks of starting treatment, but its full effects may take several months to be noticeable.
Can Flac cure prostate cancer?
No, Flac is not a cure for prostate cancer, but it can help slow the progression of the disease and manage symptoms by blocking the effects of testosterone.
Can I drink alcohol while taking Flac?
It's best to avoid alcohol while taking Flac, as both alcohol and flutamide can affect liver function, increasing the risk of liver damage.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
How long will I need to take Flac?
Flac is usually taken as part of long-term therapy for prostate cancer. The duration of treatment depends on how well the cancer responds and how well you tolerate the medication. Your healthcare provider will monitor your progress regularly.
Comprehensive Drug Guide
How Does Flac Work?
Flutamide works by blocking androgen receptors in prostate cells, preventing the binding of testosterone and other androgens. This reduces the stimulation of cancer cell growth in androgen-sensitive tissues like the prostate. By decreasing the effects of male hormones, Flac helps slow the progression of prostate cancer.
Common Dosages
The typical dosage of Flac for prostate cancer is:
- 250 mg taken three times daily (every 8 hours), often in combination with an LHRH agonist to maximize the anti-androgen effects.
Typical Dosing
- For prostate cancer: The standard dose is 250 mg orally every 8 hours (three times a day). Flac is typically used alongside other hormonal therapies to suppress androgen production.
Typical Dosing
FDA Approved Indications
- Advanced prostate cancer, often used in combination with other hormonal treatments like LHRH agonists to block testosterone production and its effects on prostate cancer cells.
Who Shouldn't Take Flac?
- Severe liver impairment or a history of liver disease.
- Known hypersensitivity to flutamide or any components of the formulation.
Advice From The Pharmacist
- Take Flac as prescribed, usually three times daily, with or without food.
- Regular blood tests, especially liver function tests, are necessary to monitor for potential side effects.
- Report any signs of liver toxicity, such as yellowing of the skin or eyes (jaundice), dark urine, persistent nausea, or fatigue, to your healthcare provider immediately.
- Do not stop taking Flac suddenly without consulting your healthcare provider, as this could worsen your condition.
Side Effects of Flac
Common Side Effects
- Hot flashes
- Diarrhea
- Nausea
- Fatigue
- Decreased libido or impotence
Uncommon/Severe Side Effects
- Liver toxicity (jaundice, dark urine, abdominal pain)
- Hemolytic anemia (low red blood cell count)
- Gynecomastia (enlargement of male breast tissue)
- Breast tenderness
Risks and Warnings of Flac
- Liver Toxicity: Flac is associated with a risk of serious liver damage. Liver function should be monitored before and during treatment. Discontinue use if significant liver toxicity is detected.
- Gynecomastia and Breast Tenderness: Men taking Flac may experience enlargement of breast tissue and breast tenderness due to hormone imbalances.
- Hot Flashes: As a common side effect of hormonal therapies for prostate cancer, Flac can cause hot flashes.
Interactions with Flac
Common Drug Interactions
- Warfarin: Flac may increase the effects of anticoagulants like warfarin, increasing the risk of bleeding. Monitoring of blood clotting times (INR) is recommended.
- Liver enzyme-inducing drugs: Medications that affect liver enzymes may alter the metabolism of flutamide, potentially increasing the risk of side effects.
Alternatives to Flac
- Bicalutamide (Casodex): Another nonsteroidal anti-androgen used for prostate cancer treatment, often preferred due to a lower incidence of liver toxicity.
- Enzalutamide (Xtandi): A more advanced anti-androgen used in the treatment of metastatic prostate cancer.
- Abiraterone (Zytiga): An androgen synthesis inhibitor used in combination with prednisone for advanced prostate cancer.
