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Firdapse
Firdapse (amifampridine) is a potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome (LEMS), a rare autoimmune disorder that affects the connection between nerves and muscles, causing muscle weakness. Firdapse helps improve muscle function by enhancing the release of acetylcholine, which is needed for muscle contraction.
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Frequently Asked Questions
How quickly does Firdapse work?
Some patients may notice improvements in muscle strength within 30 to 60 minutes of taking Firdapse, but full benefits may take several days.
Can I drive while taking Firdapse?
Firdapse may cause dizziness or drowsiness, so it is advised to avoid driving or operating heavy machinery until you know how it affects you.
Can Firdapse cause seizures?
Yes, Firdapse may increase the risk of seizures, especially at higher doses. It is important to take the medication exactly as prescribed.
Is Firdapse safe for long-term use?
Firdapse can be used long-term to manage LEMS, but regular monitoring by your healthcare provider is recommended.
What should I do if I miss a dose of Firdapse?
If you miss a dose of Firdapse, take it as soon as you remember. If it is close to your next dose, skip the missed dose and continue with your regular dosing schedule.
Comprehensive Drug Guide
How Does Firdapse Work?
Firdapse works by blocking potassium channels in nerve cells, which helps prolong the release of acetylcholine at the neuromuscular junction. This enhances communication between nerves and muscles, improving muscle strength in patients with LEMS.
Common Dosages
- Tablets: 10 mg
Typical Dosing
- The typical starting dose for Firdapse is 15 to 30 mg per day, divided into three or four doses. The dose may be increased gradually, but the maximum dose is 80 mg per day.
Typical Dosing
FDA Approved Indications
- Treatment of Lambert-Eaton myasthenic syndrome (LEMS) in adults.
Who Shouldn't Take Firdapse?
- Known hypersensitivity to amifampridine or any of its components.
- History of seizures, as Firdapse may increase seizure risk.
Advice From The Pharmacist
- Take Firdapse as directed, with or without food. Do not take more than prescribed, as it may increase the risk of seizures.
- Report any unusual symptoms such as seizures or severe weakness to your healthcare provider immediately.
- Store Firdapse at room temperature, away from moisture and heat.
Side Effects of Firdapse
Common Side Effects
- Tingling around the mouth or fingers
- Nausea
- Diarrhea
Uncommon/Severe Side Effects
- Seizures
- Allergic reactions
Risks and Warnings of Firdapse
- Seizure Risk: Firdapse may increase the risk of seizures, especially at higher doses. Patients with a history of seizures should not use Firdapse.
- Allergic Reactions: Discontinue use and seek medical attention if you experience any signs of an allergic reaction, such as hives, difficulty breathing, or swelling.
Interactions with Firdapse
Common Drug Interactions
- Other medications that lower the seizure threshold: Concurrent use of drugs that lower the seizure threshold, such as tramadol or antidepressants, may increase the risk of seizures.
Alternatives to Firdapse
- Ruzurgi (amifampridine)
- Supportive therapy for LEMS may include pyridostigmine.
