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Firazyr
Firazyr (generic name: icatibant) is a bradykinin B2 receptor antagonist used to treat acute attacks of hereditary angioedema (HAE) in adults. Hereditary angioedema is a rare genetic condition that causes severe swelling, and Firazyr works by blocking the effects of bradykinin, a substance that contributes to the swelling.
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Frequently Asked Questions
How quickly does Firazyr work?
Firazyr begins working within 30 minutes to reduce the swelling and symptoms of an HAE attack, and full relief is often seen within a few hours.
Can I use Firazyr to prevent HAE attacks?
No, Firazyr is only approved for treating acute attacks of HAE. Other medications are available for prevention.
Can I give myself Firazyr injections at home?
Yes, patients are often trained to self-administer Firazyr during an HAE attack. Your healthcare provider will show you how to inject it properly.
How often can I use Firazyr?
You can use up to 3 injections of Firazyr within 24 hours during an acute HAE attack, with each dose given 6 hours apart if needed.
Does Firazyr cause long-term side effects?
Firazyr is generally well-tolerated with few long-term side effects, though you may experience mild reactions at the injection site.
Comprehensive Drug Guide
How Does Firazyr Work?
Firazyr works by blocking bradykinin from binding to its B2 receptor, preventing the swelling and pain associated with acute attacks of hereditary angioedema (HAE). This reduces the severity and duration of the attacks.
Common Dosages
- 30 mg/3 mL subcutaneous injection
Typical Dosing
- The typical dose for acute attacks of hereditary angioedema is a single 30 mg subcutaneous injection, which can be repeated every 6 hours if necessary, up to a maximum of 3 doses in 24 hours.
Typical Dosing
FDA Approved Indications
- Acute attacks of hereditary angioedema (HAE) in adults
Who Shouldn't Take Firazyr?
- Known hypersensitivity to icatibant or any of its components
Advice From The Pharmacist
- Firazyr is injected subcutaneously, typically in the abdomen. You may be trained to self-administer the injection during an HAE attack.
- Store Firazyr at room temperature and keep it in its original packaging until ready to use.
- Always carry Firazyr with you in case of an HAE attack, and seek medical attention if symptoms do not improve after the first dose.
Side Effects of Firazyr
Common Side Effects
- Injection site reactions (pain, swelling, or redness)
- Fever
- Dizziness
Uncommon/Severe Side Effects
- Allergic reactions (anaphylaxis)
Risks and Warnings of Firazyr
- Injection Site Reactions: Most patients experience mild pain or swelling at the injection site, which usually resolves on its own.
- Hypersensitivity Reactions: Although rare, Firazyr may cause severe allergic reactions. Seek medical attention immediately if you experience signs of anaphylaxis, such as rash, difficulty breathing, or swelling of the face or throat.
Interactions with Firazyr
Common Drug Interactions
- ACE inhibitors: Combining Firazyr with ACE inhibitors can increase the risk of angioedema.
Alternatives to Firazyr
- Berinert: A C1 esterase inhibitor used to treat and prevent HAE attacks.
- Takhzyro (lanadelumab): A monoclonal antibody used to prevent HAE attacks.
- Cinryze: Another C1 esterase inhibitor used for the prevention of HAE attacks.
