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Fetzima
Fetzima (levomilnacipran) is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD) in adults. It works by increasing the levels of serotonin and norepinephrine in the brain, which help improve mood, energy levels, and overall sense of well-being. Fetzima is not indicated for anxiety disorders or other psychiatric conditions.
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Frequently Asked Questions
How long does it take for Fetzima to start working?
It may take 2 to 4 weeks to notice an improvement in symptoms of depression, though full effects may take longer.
Can I drink alcohol while taking Fetzima?
It is advisable to avoid alcohol while taking Fetzima, as it may increase the risk of side effects like dizziness or impaired judgment.
Does Fetzima cause weight gain?
Fetzima is generally not associated with significant weight gain, though individual experiences may vary.
What should I do if I miss a dose of Fetzima?
If you miss a dose, take it as soon as you remember unless it is close to your next dose. Do not double up on doses.
Is Fetzima safe for long-term use?
Yes, Fetzima can be used long-term for the treatment of major depressive disorder, but regular monitoring by your healthcare provider is recommended.
Comprehensive Drug Guide
How Does Fetzima Work?
Fetzima works by inhibiting the reuptake of serotonin and norepinephrine in the brain, which enhances the activity of these neurotransmitters. This helps alleviate the symptoms of depression, such as sadness, lack of interest, and fatigue.
Common Dosages
- Extended-release capsules: 20 mg, 40 mg, 80 mg, 120 mg
Typical Dosing
- The typical starting dose of Fetzima is 20 mg once daily for the first two days, then increased to 40 mg once daily. The dose may be adjusted up to a maximum of 120 mg per day based on response and tolerability.
Typical Dosing
FDA Approved Indications
- Treatment of major depressive disorder (MDD) in adults
Who Shouldn't Take Fetzima?
- Known hypersensitivity to levomilnacipran or any of its components.
- Uncontrolled narrow-angle glaucoma.
Advice From The Pharmacist
- Take Fetzima once daily, with or without food, at the same time each day.
- Do not stop taking Fetzima abruptly, as this may cause withdrawal symptoms. Consult your doctor before discontinuing the medication.
- Monitor for signs of increased depression or suicidal thoughts, particularly in the first few weeks of treatment.
Side Effects of Fetzima
Common Side Effects
- Nausea
- Constipation
- Sweating
- Increased heart rate
Uncommon/Severe Side Effects
- Increased blood pressure
- Suicidal thoughts or behavior (particularly in young adults)
- Serotonin syndrome
Risks and Warnings of Fetzima
- Suicidal Thoughts: Fetzima may increase the risk of suicidal thoughts and behaviors in patients under 24 years old. Close monitoring is required during the initial treatment period.
- Blood Pressure and Heart Rate: Fetzima can increase blood pressure and heart rate. Regular monitoring is recommended for patients with pre-existing heart conditions.
Interactions with Fetzima
Common Drug Interactions
- MAO inhibitors: Should not be used with or within 14 days of Fetzima, as it may increase the risk of serotonin syndrome.
- SSRIs and other SNRIs: Concurrent use increases the risk of serotonin syndrome.
Alternatives to Fetzima
- Cymbalta (duloxetine)
- Effexor XR (venlafaxine)
- Pristiq (desvenlafaxine)
