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Felbatol
Felbatol (felbamate) is an anticonvulsant used to treat seizures in patients with epilepsy, particularly for partial seizures and Lennox-Gastaut syndrome, a severe form of epilepsy in children. It is often prescribed when other medications have failed to control seizures. Due to its risk of severe side effects, it is typically used as a last resort.
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Frequently Asked Questions
Can Felbatol cure epilepsy?
No, Felbatol does not cure epilepsy, but it helps control seizures in patients for whom other treatments have failed.
Why does Felbatol require regular blood tests?
Felbatol carries a risk of serious side effects like aplastic anemia and liver failure, so regular monitoring is essential.
Can I stop taking Felbatol if my seizures are under control?
No, you should not stop taking Felbatol suddenly, as this may lead to increased seizures. Consult your doctor before making any changes.
How long does it take for Felbatol to start working?
It may take a few weeks to reach the full therapeutic effect, as the dose is gradually increased.
What should I do if I experience symptoms of liver damage while taking Felbatol?
Symptoms of liver damage include yellowing of the skin or eyes, dark urine, or severe fatigue. Seek medical attention immediately if these occur.
Comprehensive Drug Guide
How Does Felbatol Work?
The exact mechanism of Felbatol is not fully understood, but it is believed to work by modulating the activity of GABA (an inhibitory neurotransmitter) and blocking NMDA receptors involved in excitatory signaling. This helps reduce the abnormal electrical activity in the brain that causes seizures.
Common Dosages
- Tablets: 400 mg, 600 mg
- Oral suspension: 600 mg/5 mL
Typical Dosing
- For partial seizures, the typical starting dose is 1,200 mg per day, divided into two or three doses, and can be increased gradually.
- For Lennox-Gastaut syndrome, the dose is adjusted based on the patient's weight and response to treatment.
Typical Dosing
FDA Approved Indications
- Treatment of partial seizures in adults with epilepsy
- Treatment of Lennox-Gastaut syndrome in children
Who Shouldn't Take Felbatol?
- Known hypersensitivity to felbamate or any of its components.
- History of liver disease or blood dyscrasias (such as aplastic anemia).
Advice From The Pharmacist
- Regular blood tests will be required to monitor for potential side effects, such as liver function and blood cell counts.
- Felbatol can be taken with or without food, but be consistent with how you take it.
- Do not stop taking Felbatol abruptly, as this may lead to increased seizure activity.
Side Effects of Felbatol
Common Side Effects
- Dizziness
- Drowsiness
- Nausea
Uncommon/Severe Side Effects
- Aplastic anemia
- Liver failure
- Severe skin reactions
Risks and Warnings of Felbatol
- Aplastic Anemia: Felbatol has been associated with a risk of developing life-threatening aplastic anemia. Regular blood monitoring is essential.
- Liver Toxicity: Felbatol can cause severe liver damage, including liver failure. Regular liver function tests are required.
Interactions with Felbatol
Common Drug Interactions
- Carbamazepine: May lower the levels of felbamate in the blood.
- Phenytoin: Can also reduce the effectiveness of felbamate.
Alternatives to Felbatol
- Lamictal (lamotrigine)
- Keppra (levetiracetam)
- Topamax (topiramate)
