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Evrysdi
Evrysdi (risdiplam) is a splicing modifier used to treat spinal muscular atrophy (SMA), a genetic disorder that affects muscle strength and movement. Evrysdi works by increasing the production of survival motor neuron (SMN) protein, which is deficient in patients with SMA. It is used in both infants and adults.
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Frequently Asked Questions
How long does it take for Evrysdi to work?
Improvement in muscle function may be seen within a few months of starting Evrysdi, but it varies by patient.
Can Evrysdi be used in infants?
Yes, Evrysdi is approved for use in infants aged 2 months and older with SMA.
Does Evrysdi cure SMA?
No, Evrysdi does not cure SMA, but it helps slow disease progression and improve muscle function by increasing SMN protein levels.
Can Evrysdi be taken with food?
Yes, Evrysdi should be taken after a meal to ensure proper absorption.
What should I do if I miss a dose of Evrysdi?
If you miss a dose, take it as soon as you remember. If it's close to your next dose, skip the missed dose and resume your regular schedule. Do not double up doses.
Comprehensive Drug Guide
How Does Evrysdi Work?
Evrysdi works by promoting the production of functional SMN protein from the SMN2 gene. This protein is essential for the maintenance and survival of motor neurons, which are critical for muscle movement. Increasing SMN protein levels helps improve muscle function and delays disease progression in patients with SMA.
Common Dosages
- Oral solution: 0.75 mg/mL
Typical Dosing
- For patients weighing less than 20 kg: 0.2 mg/kg once daily.
- For patients weighing 20 kg or more: 5 mg once daily.
Typical Dosing
FDA Approved Indications
- Treatment of spinal muscular atrophy (SMA) in patients 2 months and older.
Who Shouldn't Take Evrysdi?
- Known hypersensitivity to risdiplam or any of its components.
Advice From The Pharmacist
- Evrysdi should be taken once daily after a meal, preferably at the same time each day.
- It is important to measure the dose using the provided oral syringe.
- Store Evrysdi in the refrigerator and use it within 60 days of mixing.
Side Effects of Evrysdi
Common Side Effects
- Fever
- Diarrhea
- Rash
Uncommon/Severe Side Effects
- Lower respiratory tract infections
- Fatigue
Risks and Warnings of Evrysdi
- Respiratory Infections: Patients taking Evrysdi are at increased risk of respiratory infections, including pneumonia, particularly in infants and children.
- Liver Function: Regular monitoring of liver function is recommended, as Evrysdi can affect liver enzymes.
Interactions with Evrysdi
Common Drug Interactions
- Hormonal contraceptives: Evrysdi may reduce the effectiveness of hormonal contraceptives, so alternative or backup contraception is recommended.
- Antibiotics: Certain antibiotics may interact with Evrysdi, so consult your healthcare provider before starting any new medications.
Alternatives to Evrysdi
- Spinraza (nusinersen)
- Zolgensma (onasemnogene abeparvovec-xioi)
