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Evotaz
Evotaz is a combination of two medications, atazanavir (a protease inhibitor) and cobicistat (a pharmacokinetic enhancer), used to treat HIV-1 infection in combination with other antiretroviral agents. Evotaz helps control HIV by preventing the virus from multiplying in the body and is part of a highly active antiretroviral therapy (HAART) regimen.
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Frequently Asked Questions
Can Evotaz cure HIV?
No, Evotaz does not cure HIV, but it helps manage the infection by reducing viral load when used in combination with other antiretroviral drugs.
How should I take Evotaz?
Take Evotaz with food once daily at the same time each day. Do not skip doses, as this can lead to drug resistance.
Does Evotaz have any dietary restrictions?
Avoid taking Evotaz with acid-reducing medications like proton pump inhibitors, as they can interfere with absorption.
Can Evotaz cause jaundice?
Yes, Evotaz may cause jaundice (yellowing of the skin or eyes) due to elevated bilirubin levels, but this is generally harmless and reversible.
Is Evotaz safe for children?
Evotaz is approved for use in pediatric patients aged 12 years and older who weigh at least 35 kg.
Comprehensive Drug Guide
How Does Evotaz Work?
Atazanavir inhibits the action of the HIV-1 protease enzyme, which is essential for the virus to mature and replicate. Cobicistat enhances the effectiveness of atazanavir by inhibiting the enzyme that metabolizes it, thus increasing its blood levels and prolonging its action.
Typical Dosing
FDA Approved Indications
- Treatment of HIV-1 infection in combination with other antiretroviral medications in adults and pediatric patients aged 12 years and older.
Who Shouldn't Take Evotaz?
- Known hypersensitivity to atazanavir, cobicistat, or any of the ingredients in Evotaz.
- Severe liver impairment.
- Concurrent use of medications highly dependent on CYP3A for clearance.
Advice From The Pharmacist
- Take Evotaz with food to enhance absorption.
- Do not miss doses, as this can lead to drug resistance. If you miss a dose and it's close to your next dose, skip the missed dose and continue with your regular schedule.
- Avoid taking Evotaz with acid-reducing medications like proton pump inhibitors, as they can reduce the effectiveness of atazanavir.
Side Effects of Evotaz
Common Side Effects
- Nausea
- Diarrhea
- Jaundice (yellowing of the skin or eyes)
Uncommon/Severe Side Effects
- Liver toxicity
- Kidney stones
- Heart rhythm problems (prolonged PR interval)
Risks and Warnings of Evotaz
- Liver Toxicity: Evotaz may cause elevated liver enzymes and liver damage, particularly in patients with hepatitis B or C co-infection. Regular liver function tests are recommended.
- Kidney Stones: Atazanavir may increase the risk of kidney stones. Drink plenty of fluids to reduce the risk.
Interactions with Evotaz
Common Drug Interactions
- Rifampin: Decreases the effectiveness of Evotaz.
- Proton Pump Inhibitors: Can reduce the absorption of atazanavir, lowering its effectiveness.
Alternatives to Evotaz
- Prezista (darunavir)
- Reyataz (atazanavir)
- Kaletra (lopinavir/ritonavir)
