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Esgic

Esgic (generic name: butalbital/acetaminophen/caffeine) is a combination medication used to treat tension headaches. It contains butalbital, a barbiturate that helps relax muscle contractions, acetaminophen, a pain reliever, and caffeine, a stimulant that improves blood flow. Esgic is typically prescribed for short-term relief of tension-type headaches.



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Frequently Asked Questions

How long does it take for Esgic to relieve a headache?
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Esgic usually starts to relieve headache symptoms within 30 to 60 minutes of taking a dose.

Can I take Esgic for migraines?
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Esgic is generally used for tension headaches, not migraines. Consult your doctor for appropriate migraine treatments.

How often can I take Esgic?
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Take Esgic as needed, but do not exceed 6 tablets/capsules per day or use it more frequently than prescribed due to the risk of dependence and liver damage.

Can Esgic cause withdrawal symptoms?
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Yes, if used regularly for an extended period, Esgic can lead to physical dependence. Stopping it suddenly may cause withdrawal symptoms, so consult your doctor before discontinuing use.

Is Esgic safe during pregnancy?
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Esgic should generally be avoided during pregnancy due to the potential risks of butalbital and acetaminophen. Always consult your healthcare provider before using any medications during pregnancy.

Comprehensive Drug Guide

How Does Esgic Work?

  • Butalbital is a barbiturate that helps reduce muscle tension and relaxes the central nervous system.
  • Acetaminophen is a pain reliever that helps alleviate headache pain.
  • Caffeine is a stimulant that improves blood flow and enhances the pain-relieving effects of acetaminophen.

Common Dosages

  • 50 mg butalbital / 325 mg acetaminophen / 40 mg caffeine tablets or capsules.

Typical Dosing

  • Take one tablet or capsule every 4 hours as needed for headache relief. Do not exceed 6 tablets/capsules in a 24-hour period.


Typical Dosing

FDA Approved Indications

  • Relief of tension headaches


Who Shouldn't Take Esgic?

  • Porphyria
  • Severe liver disease
  • Known hypersensitivity to any of the components


Advice From The Pharmacist

  • Take Esgic as prescribed. Do not take more than the recommended dose, as overuse can lead to serious side effects, including liver damage due to acetaminophen.
  • Avoid consuming alcohol while taking Esgic, as it can increase the risk of liver damage and enhance the sedative effects of butalbital.
  • Do not use Esgic for extended periods, as it can lead to dependence or tolerance.
  • If headaches become more frequent or severe while using Esgic, consult your healthcare provider.


Side Effects of Esgic

Common Side Effects

  • Drowsiness
  • Dizziness
  • Nausea


Uncommon/Severe Side Effects

  • Liver damage (due to acetaminophen)
  • Dependence or abuse
  • Respiratory depression (due to butalbital)


Risks and Warnings of Esgic

  • Liver Damage: Taking more than the recommended dose of acetaminophen can cause severe liver damage. Be cautious about using other acetaminophen-containing products while taking Esgic.
  • Abuse Potential: Butalbital is a barbiturate with a risk of dependence and abuse. Do not take Esgic more frequently or for longer than prescribed.
  • Sedation: Esgic can cause drowsiness and dizziness. Avoid driving or operating heavy machinery until you know how it affects you.


Interactions with Esgic

Common Drug Interactions

  • Alcohol: Increases the risk of liver damage and enhances the sedative effects of butalbital.
  • Other CNS depressants: Combining Esgic with other sedatives, such as benzodiazepines or opioids, can increase the risk of respiratory depression.


Alternatives to Esgic

  • Fioricet: Another combination of butalbital, acetaminophen, and caffeine used to treat tension headaches.
  • Excedrin: An over-the-counter medication containing acetaminophen, aspirin, and caffeine for treating headaches.
  • Amitriptyline: A tricyclic antidepressant often used to prevent tension-type headaches.