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Emflaza
Emflaza (deflazacort) is a corticosteroid used to treat Duchenne muscular dystrophy (DMD) in patients 2 years of age and older. It helps reduce inflammation and suppresses the immune system, which can slow the progression of muscle deterioration in people with DMD. Emflaza is part of the glucocorticoid drug class and is commonly prescribed to improve muscle strength and function in patients with this condition.
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Frequently Asked Questions
How long does it take for Emflaza to start working?
Patients may notice improvements in muscle strength within a few weeks of starting Emflaza, but it may take longer for the full effects to be seen.
Can Emflaza be used for other conditions?
Emflaza is specifically indicated for Duchenne muscular dystrophy, but other corticosteroids like prednisone are used for a wide variety of inflammatory conditions.
. Does Emflaza need to be tapered when discontinuing?
Yes, Emflaza should not be stopped abruptly. Doses should be tapered under a healthcare provider’s supervision to avoid withdrawal symptoms.
Can Emflaza cause weight gain?
Yes, weight gain is a common side effect of Emflaza, as it can increase appetite and cause fluid retention.
What should I do if I miss a dose?
If you miss a dose of Emflaza, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double up doses.
Comprehensive Drug Guide
How Does Emflaza Work?
Emflaza works by reducing inflammation and immune system activity, which slows down muscle damage in patients with Duchenne muscular dystrophy. It modulates the body’s immune response, helping to preserve muscle strength for a longer period in patients with this progressive muscle-wasting disease.
Common Dosages
- Tablet: 6 mg, 18 mg, 30 mg, and 36 mg
- Oral suspension: 22.75 mg/mL
Typical Dosing
- The typical dosing of Emflaza is based on the patient’s weight. The recommended dose is 0.9 mg/kg/day taken orally, either in tablet form or oral suspension. Dosing may be adjusted based on the patient’s response and tolerance.
Typical Dosing
FDA Approved Indications
- Treatment of Duchenne muscular dystrophy (DMD) in patients 2 years of age and older
Who Shouldn't Take Emflaza?
- Known hypersensitivity to deflazacort
- Active systemic infections
Advice From The Pharmacist
- Take Emflaza at the same time every day, preferably with food to prevent stomach upset.
- Regular monitoring is necessary due to potential side effects, including weight gain and increased risk of infections.
- Avoid exposure to infections like chickenpox or measles while on Emflaza, as the immune system may be weakened.
Side Effects of Emflaza
Common Side Effects
- Weight gain
- Increased appetite
- Mood changes
- Upper respiratory infections
Uncommon/Severe Side Effects
- Increased risk of infections
- Bone thinning (osteoporosis)
- High blood pressure
- Cushing's syndrome (increased fat around the face and neck)
Risks and Warnings of Emflaza
- Infection Risk: Emflaza can suppress the immune system, increasing the risk of infections. Patients should avoid exposure to contagious illnesses.
- Bone Health: Long-term use may lead to osteoporosis or bone fractures. Calcium and vitamin D supplements may be recommended to support bone health.
Interactions with Emflaza
Common Drug Interactions
- Live vaccines: Avoid receiving live vaccines while on Emflaza due to its immunosuppressive effects.
- Blood thinners: Emflaza may increase the risk of bleeding when taken with blood-thinning medications like warfarin.
Alternatives to Emflaza
- Prednisone: Another corticosteroid used for Duchenne muscular dystrophy.
- Corticotropin (ACTH): Sometimes used to manage inflammatory conditions.
- Exondys 51 (eteplirsen): A treatment specifically for certain mutations of DMD.
