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E.E.S. 400
E.E.S. 400 is a brand name for erythromycin ethylsuccinate, an antibiotic used to treat a wide variety of bacterial infections. Erythromycin belongs to the macrolide class of antibiotics, which work by stopping the growth of bacteria. E.E.S. 400 is often prescribed for respiratory tract infections, skin infections, and certain sexually transmitted infections. It is not effective against viral infections like the common cold or flu.
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Frequently Asked Questions
Can I take E.E.S. 400 with food?
Yes, you can take E.E.S. 400 with or without food. Taking it with food or milk may help prevent stomach upset.
How long should I take E.E.S. 400?
Typically, you will take E.E.S. 400 for 7 to 14 days, depending on the type and severity of your infection. Always complete the full course of antibiotics as prescribed, even if you feel better.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses to make up for a missed one.
Can I drink alcohol while taking E.E.S. 400?
It’s best to avoid alcohol while taking E.E.S. 400, as it may increase the risk of side effects like stomach upset and liver issues.
What should I do if I experience severe diarrhea while taking E.E.S. 400?
Severe diarrhea, especially if it is watery or contains blood, can be a sign of a serious intestinal condition called Clostridium difficile-associated diarrhea. Contact your healthcare provider immediately if this occurs. Do not use anti-diarrheal medications without medical advice.
Comprehensive Drug Guide
How Does E.E.S. 400 Work?
Erythromycin works by binding to the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. This action stops bacteria from growing and reproducing, allowing the immune system to eliminate the infection. E.E.S. 400 is bacteriostatic, meaning it halts bacterial growth rather than killing the bacteria directly.
Common Dosages
- Oral tablets: 400 mg
- Oral suspension: 200 mg/5 mL, 400 mg/5 mL
Typical Dosing
- The typical adult dose for most infections is 400 mg (1 tablet) every 6 to 12 hours, depending on the severity and type of infection.
- In children, the dose is based on body weight and may vary depending on the condition being treated.
- The duration of treatment usually lasts 7 to 14 days, depending on the infection.
Typical Dosing
FDA Approved Indications
- Respiratory tract infections (e.g., pneumonia, bronchitis)
- Skin and soft tissue infections
- Pertussis (whooping cough)
- Diphtheria
- Syphilis and gonorrhea in individuals allergic to penicillin
- Certain gastrointestinal infections caused by susceptible bacteria
Who Shouldn't Take E.E.S. 400?
- Known hypersensitivity to erythromycin or any component of the formulation
- Severe liver disease
- Concurrent use of medications that are known to interact with erythromycin (such as cisapride, pimozide, ergotamine, or lovastatin)
Advice From The Pharmacist
- Take E.E.S. 400 by mouth, with or without food, usually 1 to 2 times daily, or as directed by your healthcare provider.
- Shake the suspension well before each dose, if using the liquid form.
- Complete the full course of treatment even if you feel better after a few days. Stopping the medication too early may allow the bacteria to continue growing, leading to a return of the infection.
- If you experience gastrointestinal upset, try taking it with food or milk.
Side Effects of E.E.S. 400
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Loss of appetite
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Liver toxicity
- Hearing loss (especially in elderly patients)
- Severe colitis or diarrhea due to overgrowth of Clostridium difficile
Risks and Warnings of E.E.S. 400
- QT Prolongation: Erythromycin can cause QT prolongation, which may lead to serious heart arrhythmias. Patients with a history of heart conditions or those on medications affecting the heart rhythm should use caution.
- Liver Toxicity: Erythromycin is metabolized in the liver, so patients with pre-existing liver conditions or those taking hepatotoxic drugs should be monitored closely.
- Drug Interactions: E.E.S. 400 can interact with a wide range of medications, including certain cholesterol-lowering drugs (statins), anticonvulsants, and anticoagulants. Ensure your healthcare provider is aware of all medications you are taking.
Interactions with E.E.S. 400
Common Drug Interactions
- CYP3A4 Inhibitors: Erythromycin is metabolized by the liver enzyme CYP3A4, and concurrent use with drugs that inhibit this enzyme (e.g., azole antifungals, calcium channel blockers) can increase the risk of side effects.
- Statins: Combining erythromycin with statins (e.g., lovastatin, simvastatin) can increase the risk of muscle damage (rhabdomyolysis).
- Warfarin: Erythromycin may increase the effects of blood-thinning medications like warfarin, leading to a higher risk of bleeding.
Alternatives to E.E.S. 400
- Azithromycin: A macrolide antibiotic similar to erythromycin but with fewer gastrointestinal side effects and a more convenient dosing regimen.
- Clarithromycin: Another macrolide, often used as an alternative to erythromycin for similar infections.
- Amoxicillin: A penicillin-class antibiotic that is commonly prescribed for bacterial infections but may not be suitable for those with penicillin allergies.
- Levofloxacin: A fluoroquinolone antibiotic often used in cases of bacterial resistance or for patients allergic to macrolides.
