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Dyrenium
Dyrenium, commonly known as Triamterene, is a medication employed in the management of fluid buildup in the body, a condition medically termed Edema. This may occur due to heart disease, liver cirrhosis, or kidney disease. It exerts its effect as a diuretic and can also hamper low potassium levels. Possible side effects may encompass nausea, vomiting, and frequent urination. However, your physician would prescribe this after weighing the benefits and the side effects.
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Frequently Asked Questions
Does Dyrenium affect blood pressure?
Yes. Dyrenium can lower high blood pressure by helping your body eliminate excess fluid.
Does Dyrenium make you urinate more?
Yes, Dyrenium is a type of diuretic or "water pill
What should I do if I miss a dose of Dyrenium?
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose, and go back to your regular dosing schedule. Do not double doses.
Comprehensive Drug Guide
How Does Dyrenium Work?
Dyrenium, a potassiumsparing diuretic, functions by inhibiting the exchange of sodium for potassium in the distal renal tubule. This promotes the excretion of sodium and water and the conservation of potassium ions.
What is Dyrenium Used For?
FDA indications: Dyrenium is principally used in the management of edema secondary to heart failure, liver cirrhosis, or nephrotic syndrome. It is also effective in treating patients requiring a diuretic who also have a risk of developing hypokalemia.
Offlabel uses: It's also been used offlabel for the treatment of certain types of kidney stones.
Common Dosages
Capsules: 50mg, 100mg
Typical Dosing
FDA Approved Indications
- For Edema treatment: Initial: 100mg twice daily, followed by an adjustment depending on the response.
- For diureticinduced hypokalemia: initial: 50mg to 100mg daily in a single or divided dose, modification can be done based on the response.
Who Shouldn't Take Dyrenium?
- Patients who have kidney disease or are unable to urinate.
- Patients with high potassium levels.
- Patients taking similar potassiumsparing diuretics or potassium supplements.
- Patients who are allergic to Dyrenium.
Advice From The Pharmacist
- This medication should be taken after meals to avoid stomach upset.
- It can influence potassium levels in the body. Regular blood tests would be needed to monitor these levels.
- Dyrenium may increase the frequency of urination. Avoid taking it within 4 hours before bedtime to prevent disturbance during sleep.
- While on this medication, the need for diet modifications, such as reducing salt or potassium intake, should be discussed with a healthcare provider.
- Regular monitoring of blood pressure and kidney function is crucial when on this medication.
- It is essential to take this medication regularly for the maximum benefit.
Side Effects of Dyrenium
Common Side Effects
- Nausea, vomiting
- Leg cramps
- Dizziness
- Frequent urination
Uncommon/Severe Side Effects
- Uncommon side effects:
- Abnormal heartbeat
- Mood changes
- Abdominal or stomach pain
- Decreased sexual ability
- Rare side effects:
- Yellowing skin or eyes
- Severe side effects:
- Blurred vision, headache, or extremely dizzy
- Unexplained rash
- Unusual fatigue or weakness
- Symptoms of infection such as fever, chills, or persistent sore throat
- Signs of a high potassium blood level
Risks and Warnings of Dyrenium
- Use Dyrenium cautiously in patients with severe liver or heart disease as it can exacerbate certain conditions.
- Patients with high potassium levels should abstain from taking Dyrenium as it could lead to a serious imbalance.
- The use of this drug should be discussed with your healthcare provider for patients with a history of kidney stones.
- Inform your doctor if you are pregnant, considering pregnancy, or breastfeeding as the safety of this drug is unknown in such conditions.
Interactions with Dyrenium
Common Drug Interactions
- Lithium
- ACE inhibitors (like lisinopril)
- Angiotensin II receptor blockers (like valsartan, losartan)
- Other potassiumsparing diuretics
- Potassium supplements
Alternatives to Dyrenium
- Spironolactone
- Amiloride
- Eplerenone
