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Duexis
Duexis is a combination medication that includes ibuprofen and famotidine. It is used primarily for the relief of pain and inflammation associated with conditions like osteoarthritis and rheumatoid arthritis, while also providing protection against gastric ulcers that can be caused by long-term NSAID use. Duexis helps manage both pain and the gastrointestinal side effects associated with nonsteroidal anti-inflammatory drugs (NSAIDs).
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Frequently Asked Questions
How long does it take for Duexis to work?
Patients may start to feel relief from pain within 1 to 2 hours after taking Duexis.
Can Duexis be taken during pregnancy?
Duexis should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider for personalized advice.
What should I do if I miss a dose of Duexis?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while taking Duexis?
There are no specific dietary restrictions while taking Duexis, but taking it with food may help reduce gastrointestinal side effects.
Is Duexis safe for long-term use?
Duexis may be safe for long-term use under the supervision of a healthcare provider, with regular monitoring for potential side effects and effectiveness in managing pain and inflammation.
Comprehensive Drug Guide
How Does Duexis Work?
- Ibuprofen: Reduces pain and inflammation by inhibiting the production of prostaglandins, which are substances in the body that mediate inflammation and pain.
- Famotidine: Decreases stomach acid production, helping to protect the gastrointestinal lining from ulcers and irritation that may be caused by NSAID use.
Common Dosages
- Tablets: Usually available in a formulation containing 800 mg of ibuprofen and 26.6 mg of famotidine.
Typical Dosing
- For pain management: The usual dosage is 1 tablet taken orally three times a day, with or without food, as directed by a healthcare provider.
Typical Dosing
FDA Approved Indications
- Relief of pain and inflammation in conditions such as osteoarthritis and rheumatoid arthritis.
- Prevention of NSAID-associated gastric ulcers in patients at risk
Who Shouldn't Take Duexis?
- Known hypersensitivity to ibuprofen, famotidine, or any components of the formulation.
- Active peptic ulcer disease or gastrointestinal bleeding.
- Severe renal impairment or liver disease.
Advice From The Pharmacist
- Take Duexis exactly as prescribed and do not exceed the recommended dosage.
- Monitor for any signs of gastrointestinal bleeding, such as black or bloody stools, and report these to your healthcare provider immediately.
- Be aware of potential side effects, including dizziness and gastrointestinal discomfort.
Side Effects of Duexis
Common Side Effects
- Nausea
- Diarrhea
- Dizziness
- Heartburn
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, swelling, or difficulty breathing)
- Gastrointestinal bleeding or ulcers
Risks and Warnings of Duexis
- Gastrointestinal Risks: Prolonged use of NSAIDs can increase the risk of gastrointestinal bleeding and ulcers; regular monitoring may be necessary.
- Cardiovascular Risks: NSAIDs may increase the risk of heart attack or stroke; patients with cardiovascular risk factors should be monitored.
Interactions with Duexis
Common Drug Interactions
- Other NSAIDs: Caution should be exercised when using Duexis with other NSAIDs or aspirin, as this may increase the risk of gastrointestinal bleeding.
- Anticoagulants: Concurrent use with blood thinners should be monitored closely due to the increased risk of bleeding.
Alternatives to Duexis
- Other NSAID formulations: Such as naproxen or celecoxib, may be considered for pain relief.
- Non-pharmacological approaches: Physical therapy, exercise, and other non-drug therapies may help manage pain and inflammation.
