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Doral
Doral (generic name: quazepam) is a medication primarily used for the treatment of insomnia. It belongs to the benzodiazepine class of drugs and is known for its sedative properties. Doral helps individuals fall asleep more quickly and stay asleep longer, making it effective for those with sleep disturbances.
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Frequently Asked Questions
How long does it take for Doral to work?
Patients may begin to notice effects within 30 minutes, with peak effects occurring within 1 to 2 hours after dosing.
Can Doral be taken during pregnancy?
Doral should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider for personalized advice.
What should I do if I miss a dose of Doral?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while taking Doral?
There are no specific dietary restrictions while taking Doral, but avoiding alcohol is recommended, as it may increase the risk of side effects.
Is Doral safe for long-term use?
Doral can be safe for long-term use under the supervision of a healthcare provider, but regular monitoring is essential to mitigate the risk of dependence and withdrawal symptoms.
Comprehensive Drug Guide
How Does Doral Work?
- Enhancing GABA activity: It increases the effectiveness of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits nerve transmission in the brain, leading to a calming effect.
- Reducing neuronal excitability: This results in sedation, muscle relaxation, and anxiolytic effects.
Common Dosages
- Tablets: Available in strengths of 7.5 mg and 15 mg.
Typical Dosing
- For insomnia: The usual adult dosage is 7.5 mg taken 30 minutes before bedtime, with the option to increase to 15 mg if needed. The maximum recommended dose is 15 mg.
Typical Dosing
FDA Approved Indications
- Treatment of insomnia characterized by difficulties with sleep initiation and/or sleep maintenance.
Who Shouldn't Take Doral?
- Known hypersensitivity to quazepam or any components of the formulation.
- Severe respiratory insufficiency or sleep apnea, as benzodiazepines can exacerbate respiratory depression.
- Acute narrow-angle glaucoma.
Advice From The Pharmacist
- Take Doral exactly as prescribed, and do not adjust the dose without consulting your healthcare provider.
- Use caution when driving or operating machinery until you know how Doral affects you, as it may cause drowsiness or dizziness.
- Be aware of the potential for dependence and withdrawal symptoms if Doral is discontinued abruptly after prolonged use; consult your healthcare provider for a tapering schedule.
Side Effects of Doral
Common Side Effects
- Drowsiness
- Dizziness
- Fatigue
- Confusion
- Memory problems
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, swelling, or difficulty breathing)
- Respiratory depression, especially with overdose or in sensitive individuals.
Risks and Warnings of Doral
- Risk of Abuse: Due to its potential for addiction, Doral should be used with caution in patients with a history of substance abuse.
- Cognitive Effects: Use caution in elderly patients, as benzodiazepines can increase the risk of cognitive impairment and falls.
Interactions with Doral
Common Drug Interactions
- Other CNS depressants: Caution should be exercised when using Doral with other medications that can cause sedation, such as opioids, benzodiazepines, and alcohol, due to the increased risk of respiratory depression and sedation.
- MAO inhibitors: Concurrent use with monoamine oxidase inhibitors can lead to serious side effects and should be avoided.
Alternatives to Doral
- Other benzodiazepines: Such as lorazepam or temazepam, which may also be used for insomnia treatment.
- Non-benzodiazepine sleep aids: Such as zolpidem or eszopiclone, which may have a lower risk of dependence.
