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Dificid
Dificid (generic name: fidaxomicin) is an antibiotic used to treat Clostridioides difficile-associated diarrhea (CDAD), a type of bacterial infection that causes severe, watery diarrhea. It belongs to the macrolide antibiotics drug class, though it is a narrow-spectrum antibiotic specifically targeting the bacteria causing C. difficile infections. By inhibiting bacterial RNA synthesis, Dificid helps reduce the severity of the infection and prevent recurrence.
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Frequently Asked Questions
How long does it take for Dificid to start working?
Most patients begin to feel relief from symptoms within 2-3 days of starting Dificid, but the full course of 10 days should be completed to prevent recurrence.
Can I take Dificid with other antibiotics?
It's best to avoid combining Dificid with other antibiotics unless instructed by your healthcare provider, as this could decrease its effectiveness.
Does Dificid cause diarrhea?
While Dificid treats diarrhea caused by C. difficile, some patients may experience diarrhea as a side effect. It’s important to stay hydrated and inform your healthcare provider if symptoms worsen.
What should I do if I miss a dose of Dificid?
If you miss a dose, take it as soon as you remember unless it is close to your next dose. Do not take two doses at once to make up for the missed dose.
Is Dificid safe for long-term use?
Dificid is typically prescribed for a 10-day course, and long-term use is not recommended. If symptoms persist or return, consult your healthcare provider for further evaluation.
Comprehensive Drug Guide
How Does Dificid Work?
Dificid works by inhibiting bacterial RNA polymerase, which is essential for bacterial RNA synthesis. This prevents C. difficile from producing proteins and multiplying, ultimately leading to the death of the bacteria. Unlike broader-spectrum antibiotics, Dificid primarily targets C. difficile, minimizing the impact on beneficial gut bacteria.
Common Dosages
- Tablets: 200 mg
- Oral suspension: 40 mg/mL
Typical Dosing
- The typical dosing for Dificid in adults and pediatric patients is 200 mg twice daily for 10 days. In pediatric patients, dosing for the oral suspension is based on weight.
Typical Dosing
FDA Approved Indications
- Clostridioides difficile-associated diarrhea (CDAD) in adults and pediatric patients aged 6 months and older.
Who Shouldn't Take Dificid?
- Known hypersensitivity to fidaxomicin or any component of the formulation.
- Severe allergies to other macrolide antibiotics.
Advice From The Pharmacist
- Take Dificid exactly as prescribed, usually twice daily for 10 days, with or without food.
- Do not skip doses or stop the medication early, as this could increase the risk of the infection returning.
- Stay hydrated during treatment, especially if you are experiencing diarrhea.
- Inform your healthcare provider if you are pregnant, breastfeeding, or taking other antibiotics, as Dificid should not be combined with certain medications.
Side Effects of Dificid
Common Side Effects
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Breathing difficulties or anaphylaxis
- Increased risk of C. difficile recurrence if not taken as directed
Risks and Warnings of Dificid
- Allergic Reactions: If you experience severe allergic reactions such as swelling of the face or difficulty breathing, discontinue use and seek medical attention immediately.
- Risk of Recurrence: Stopping the medication early or skipping doses may increase the risk of C. difficile infection recurrence.
- Use in Pregnant or Breastfeeding Women: Limited data is available on the safety of Dificid during pregnancy or breastfeeding. Consult your healthcare provider before use.
Interactions with Dificid
Common Drug Interactions
- Macrolide antibiotics: Using other macrolide antibiotics like erythromycin with Dificid may increase the risk of side effects.
- Other antibacterials: Concurrent use of other antibiotics may decrease the effectiveness of Dificid.
- Immunosuppressants: Certain immunosuppressive medications may interact with Dificid, so consult your healthcare provider before combining treatments.
Alternatives to Dificid
- Vancomycin (oral): Another antibiotic commonly used to treat C. difficile infections.
- Metronidazole: An older treatment for C. difficile but less effective for severe cases.
- Bezlotoxumab: A monoclonal antibody used to reduce the recurrence of C. difficile infections.
- Fecal microbiota transplant (FMT): In severe or recurrent cases, FMT is sometimes considered to restore healthy gut bacteria.
