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Diasoxia
Diasoxia is a medication used to treat hypoglycemia (low blood sugar), particularly in individuals with conditions like hyperinsulinism or certain forms of glycogen storage disease. It works by inhibiting the release of insulin from the pancreas, helping to raise blood sugar levels. It belongs to the diazoxide drug class, a non-diuretic benzothiadiazine, and is typically prescribed for patients who struggle to maintain adequate blood glucose levels due to excess insulin production.
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Frequently Asked Questions
How quickly does Diasoxia work?
Diasoxia begins to work within hours to help stabilize blood sugar levels, but full effects may take several days to manifest.
Can I take Diasoxia long-term?
Yes, many patients take Diasoxia long-term under close monitoring, especially for conditions like hyperinsulinism.
What should I do if I experience fluid retention while taking Diasoxia?
Contact your healthcare provider if you notice swelling in your legs or feet or significant weight gain, as this could indicate fluid retention.
Can Diasoxia cause high blood sugar?
Yes, Diasoxia can raise blood sugar levels, so regular monitoring is essential to prevent hyperglycemia.
Can I stop taking Diasoxia if my symptoms improve?
You should not stop taking Diasoxia without consulting your healthcare provider, as your blood sugar levels could drop dangerously low if the medication is stopped abruptly.
Comprehensive Drug Guide
How Does Diasoxia Work?
Diasoxia works by inhibiting the release of insulin from the pancreas. By reducing insulin secretion, it prevents hypoglycemia and helps raise blood sugar levels. This is particularly useful in conditions where the pancreas releases too much insulin, such as hyperinsulinism.
Common Dosages
- Capsules: 50 mg, 100 mg
- Oral suspension: 50 mg/mL
Typical Dosing
- The typical starting dose of Diasoxia for treating hypoglycemia is 3-8 mg/kg per day, divided into two to three doses. The exact dose is determined by the patient's weight and response to the medication.
Typical Dosing
FDA Approved Indications
- Hypoglycemia due to hyperinsulinism
- Glycogen storage disease (in select cases)
Who Shouldn't Take Diasoxia?
- Known hypersensitivity to diazoxide or any of its components
- Heart failure or fluid retention
- Pulmonary hypertension
Advice From The Pharmacist
- Take Diasoxia with food to reduce the risk of stomach upset.
- Monitor your blood sugar levels regularly to avoid both high and low extremes.
- Weigh yourself regularly, as this medication can cause fluid retention and swelling in some individuals.
- Avoid taking other medications that may affect blood sugar without consulting your doctor.
Side Effects of Diasoxia
Common Side Effects
- Fluid retention (swelling in the legs or feet)
- Increased heart rate
- Nausea or vomiting
- Hyperglycemia (high blood sugar)
Uncommon/Severe Side Effects
- Heart failure
- Pulmonary edema
- Hypertension
Risks and Warnings of Diasoxia
- Fluid Retention: Diasoxia can cause significant fluid retention, leading to heart or lung complications, especially in patients with underlying heart disease.
- Hyperglycemia: Since Diasoxia increases blood sugar levels, there is a risk of hyperglycemia. Regular monitoring is essential to avoid this.
- Heart Failure: In some cases, Diasoxia can lead to or worsen heart failure. Patients with a history of heart issues should be closely monitored.
Interactions with Diasoxia
Common Drug Interactions
- Diuretics: May increase the risk of fluid retention.
- Insulin or other blood-sugar-lowering medications: Combining with Diasoxia may result in unpredictable blood sugar levels.
- Antihypertensives: May interact with Diasoxia, affecting blood pressure control.
Alternatives to Diasoxia
- Glucagon: Used in emergency situations to rapidly raise blood sugar levels.
- Octreotide: Sometimes used to manage hyperinsulinism and prevent hypoglycemia.
- Corticosteroids: Used in certain cases to help increase blood glucose levels.
