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Diadimaxia
Diadimaxia (generic name: metformin hydrochloride and dapagliflozin) is a combination medication used for the management of type 2 diabetes mellitus. It combines two effective agents: metformin, which helps control blood sugar levels by improving insulin sensitivity and decreasing glucose production in the liver, and dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by preventing glucose reabsorption in the kidneys, thereby promoting its excretion in urine. This combination helps achieve better glycemic control in patients with type 2 diabetes.
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Frequently Asked Questions
How long does it take for Diadimaxia to work?
Patients may start to notice improvements in blood sugar control within a few weeks of starting treatment.
Can Diadimaxia be taken during pregnancy?
Diadimaxia should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider for personalized advice.
What should I do if I miss a dose of Diadimaxia?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while taking Diadimaxia?
There are no specific dietary restrictions, but maintaining a balanced diet and monitoring carbohydrate intake is important for diabetes management.
Is Diadimaxia safe for long-term use?
Diadimaxia can be safe for long-term use under the supervision of a healthcare provider, with regular monitoring for potential side effects and effectiveness in managing type 2 diabetes.
Comprehensive Drug Guide
How Does Diadimaxia Work?
- Metformin: Reduces hepatic glucose production and enhances insulin sensitivity, leading to improved glucose uptake by peripheral tissues.
- Dapagliflozin: Inhibits SGLT2 in the proximal renal tubules, which decreases glucose reabsorption, resulting in increased urinary glucose excretion and lower blood sugar levels.
Common Dosages
- Available in combination strengths of metformin 500 mg / dapagliflozin 10 mg and metformin 1000 mg / dapagliflozin 10 mg.
Typical Dosing
- For type 2 diabetes management: The usual starting dose is one tablet taken orally once daily, preferably with the evening meal to reduce gastrointestinal side effects.
Typical Dosing
FDA Approved Indications
- Management of type 2 diabetes mellitus in conjunction with diet and exercise.
Who Shouldn't Take Diadimaxia?
- Known hypersensitivity to metformin, dapagliflozin, or any components of the formulation.
- Severe renal impairment (eGFR < 30 mL/min).
- Active bladder cancer (for dapagliflozin).
- Diabetic ketoacidosis.
Advice From The Pharmacist
- Take Diadimaxia exactly as prescribed, and do not adjust the dose without consulting your healthcare provider.
- Monitor blood glucose levels regularly to assess treatment effectiveness.
- Stay well-hydrated, as SGLT2 inhibitors can increase the risk of urinary tract infections and dehydration.
Side Effects of Diadimaxia
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Increased urination
- Risk of urinary tract infections
Uncommon/Severe Side Effects
- Lactic acidosis (a rare but serious condition associated with metformin)
- Kidney problems
- Hypoglycemia, especially if taken with other antidiabetic medications.
Risks and Warnings of Diadimaxia
- Renal Function: Regular monitoring of kidney function is essential, especially before initiating treatment and during therapy.
- Lactic Acidosis: Awareness of symptoms (muscle pain, difficulty breathing, abdominal pain, dizziness) is crucial, as it requires immediate medical attention.
- Volume Depletion: Caution should be exercised in patients at risk of dehydration, particularly those with concurrent diuretic use.
Interactions with Diadimaxia
Common Drug Interactions
- Other antidiabetic agents: The risk of hypoglycemia may increase when used with insulin or sulfonylureas.
- Diuretics: Can increase the risk of dehydration and renal impairment.
Alternatives to Diadimaxia
- Other combinations: Such as metformin with sitagliptin or glyburide for managing blood sugar levels.
- Insulin therapy: May be considered for patients with more severe diabetes or those not achieving adequate control with oral medications.
