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Dengvaxia
Dengvaxia (generic name: dengue tetravalent vaccine, live) is a vaccine used to prevent dengue fever caused by the dengue virus. Dengue is transmitted by mosquitoes and can lead to severe complications, such as dengue hemorrhagic fever and dengue shock syndrome. Dengvaxia is designed to protect individuals from all four serotypes of the dengue virus and is primarily recommended for people living in or traveling to areas where dengue is endemic.
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Frequently Asked Questions
How long does Dengvaxia provide protection?
Dengvaxia provides long-term protection, especially for individuals who have previously had a dengue infection. The full extent of immunity may depend on completing all three doses of the vaccine.
Can Dengvaxia be used for individuals traveling to dengue-endemic areas?
Dengvaxia is only recommended for people who have already had a confirmed case of dengue. Travelers who have not previously had dengue should focus on mosquito prevention strategies rather than vaccination.
What should I do if I miss a dose of Dengvaxia?
If you miss a dose, schedule a new appointment as soon as possible to ensure you complete the vaccine series and receive full protection.
Can Dengvaxia be given to children?
Yes, Dengvaxia is approved for children aged 9 to 16 years who have previously had a confirmed dengue infection.
Is Dengvaxia safe during pregnancy?
There is limited information on the use of Dengvaxia during pregnancy. Pregnant women should discuss the risks and benefits with their healthcare provider before receiving the vaccine.
Comprehensive Drug Guide
How Does Dengvaxia Work?
Dengvaxia works by stimulating the immune system to produce antibodies against the dengue virus. It contains weakened forms of all four serotypes of the virus, which helps the body develop immunity without causing the disease. This provides protection against future infections from the virus, particularly in individuals who have previously been infected.
Common Dosages
- Dengvaxia is available as a subcutaneous injection and is typically administered in a three-dose series, with doses given six months apart.
Typical Dosing
- For dengue prevention: Dengvaxia is given as three injections, with the second and third doses administered 6 months after the previous dose.
Typical Dosing
FDA Approved Indications
- Dengue fever in individuals aged 9 to 16 who have previously had a confirmed dengue infection and live in endemic areas.
Who Shouldn't Take Dengvaxia?
- No prior history of dengue infection (it may increase the risk of severe dengue in these individuals)
- Known hypersensitivity to any components of the vaccine
- Severe immunodeficiency or immunosuppressive conditions
Advice From The Pharmacist
- Dengvaxia is only recommended for individuals who have previously had a confirmed dengue infection. A blood test to confirm past infection is usually required before starting the vaccine series.
- Complete the full vaccine series (three doses) to ensure full protection.
- If you are planning to travel to an area where dengue is endemic, consult your healthcare provider about vaccination options and timing.
Side Effects of Dengvaxia
Common Side Effects
- Injection site pain or swelling
- Fever
- Headache
- Fatigue
Uncommon/Severe Side Effects
- Severe allergic reactions
- Anaphylaxis
- Increased risk of severe dengue in individuals without prior dengue infection
Risks and Warnings of Dengvaxia
- Severe Dengue Risk: Dengvaxia can increase the risk of severe dengue in individuals who have not previously been infected with the virus. Therefore, it is only recommended for those with a history of dengue infection.
- Allergic Reactions: As with any vaccine, there is a risk of severe allergic reactions. Seek immediate medical attention if you experience symptoms such as swelling, rash, or difficulty breathing after receiving the vaccine.
Interactions with Dengvaxia
Common Drug Interactions
- Immunosuppressive therapies: Individuals on medications that suppress the immune system, such as corticosteroids or chemotherapy, may have a reduced immune response to Dengvaxia.
- Other live vaccines: Administering multiple live vaccines may require careful timing to ensure effectiveness.
Alternatives to Dengvaxia
- There are no other vaccines currently approved for the prevention of dengue fever. Prevention through mosquito control and personal protective measures (such as insect repellent and mosquito nets) is crucial in areas where dengue is endemic.
