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Delstrigo
Delstrigo is a combination antiretroviral medication used to treat HIV-1 in adults. It contains doravirine, lamivudine, and tenofovir disoproxil fumarate (TDF), which work together to suppress the replication of the HIV virus in the body, helping to maintain an undetectable viral load and improve immune function. By preventing the virus from multiplying, Delstrigo helps slow the progression of HIV and reduces the risk of developing AIDS.
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Frequently Asked Questions
How long does it take for Delstrigo to suppress HIV?
Delstrigo can help suppress viral load within a few weeks of starting treatment, but full suppression to an undetectable level may take several months.
Can I miss a dose of Delstrigo?
It’s important to take Delstrigo every day as prescribed. Missing doses can lead to an increase in viral load and the development of drug resistance.
What should I do if I miss a dose of Delstrigo?
If you miss a dose, take it as soon as you remember, unless it’s close to your next scheduled dose. Do not double up.
Is Delstrigo safe for long-term use?
Yes, Delstrigo is generally safe for long-term use, but regular monitoring of kidney function and bone density is recommended due to potential side effects.
Can Delstrigo be taken with other medications?
Always inform your healthcare provider of any other medications you are taking, as certain drugs may interact with Delstrigo and affect its efficacy.
Comprehensive Drug Guide
How Does Delstrigo Work?
Delstrigo works by inhibiting the action of reverse transcriptase, an enzyme that HIV needs to replicate its genetic material and multiply in the body. Doravirine blocks the enzyme's activity through non-nucleoside inhibition, while lamivudine and tenofovir disoproxil fumarate act as nucleoside analogs, mimicking the building blocks of the virus's genetic material, causing faulty replication and preventing the virus from reproducing.
Common Dosages
- 100 mg doravirine
- 300 mg lamivudine
- 300 mg tenofovir disoproxil fumarate
Typical Dosing
- For HIV treatment: The recommended dose is one tablet of Delstrigo taken once daily with or without food.
Typical Dosing
FDA Approved Indications
- HIV-1 infection in adults who have no antiretroviral treatment history or to replace their current regimen in adults who are virologically suppressed.
Who Shouldn't Take Delstrigo?
- Severe renal impairment (creatinine clearance < 30 mL/min)
- Known hypersensitivity to doravirine, lamivudine, tenofovir, or any other components of the formulation
Advice From The Pharmacist
- Take Delstrigo exactly as prescribed, once daily, at the same time each day. Adherence to the dosing schedule is crucial for maintaining viral suppression.
- If you miss a dose, take it as soon as you remember unless it’s close to the next dose. Do not take two doses at once.
- Keep regular follow-up appointments to monitor your viral load and kidney function while on Delstrigo.
Side Effects of Delstrigo
Common Side Effects
- Nausea
- Diarrhea
- Fatigue
- Headache
- Dizziness
Uncommon/Severe Side Effects
- Kidney problems or worsening of pre-existing kidney disease
- Bone density loss (osteoporosis)
- Lactic acidosis (a rare but serious buildup of lactic acid in the blood)
Risks and Warnings of Delstrigo
- Kidney Function: Tenofovir in Delstrigo may cause or worsen kidney disease. Regular monitoring of kidney function is important during treatment.
- Bone Density: Tenofovir can cause bone thinning or osteoporosis, particularly in long-term use. Calcium and vitamin D supplementation may be recommended.
- Lactic Acidosis: While rare, NRTIs (lamivudine and tenofovir) may cause lactic acidosis, a serious condition that requires immediate medical attention.
Interactions with Delstrigo
Common Drug Interactions
- Rifampin: Reduces the effectiveness of doravirine, leading to decreased HIV suppression.
- Anticonvulsants: Drugs like carbamazepine and phenobarbital may reduce the effectiveness of Delstrigo.
- NSAIDs: Non-steroidal anti-inflammatory drugs like ibuprofen may increase the risk of kidney problems when used with tenofovir.
Alternatives to Delstrigo
- Biktarvy: A single-tablet regimen containing bictegravir, emtricitabine, and tenofovir alafenamide.
- Triumeq: A combination tablet containing dolutegravir, abacavir, and lamivudine.
- Genvoya: A combination of elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide.
