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Danazol
Danazol is a synthetic steroid that impacts the pituitary gland, ovaries, and adrenal system. It's primarily used for hormonerelated conditions, such as endometriosis and fibrocystic breast disease. It can also help in reducing bleeding for people with hereditary angioedema. Some common side effects include acne, unusual hair growth, weight gain, and voice changes. As always, your doctor will weigh these issues against the benefits.
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Frequently Asked Questions
Can I just stop taking Danazol once my symptoms are relieved?
No, stopping the drug abruptly may lead to withdrawal symptoms. Always consult your doctor before you stop or start any medication.
Can I take Danazol if I am trying to get pregnant?
No, Danazol can harm an unborn baby. You should stop taking this medication if you're trying to get pregnant.
Does Danazol cause weight gain?
Yes, one of the common side effects is weight gain.
I missed a dose of Danazol, what should I do?
If it's close to the time of your next dose, skip the missed dose. Otherwise, take it as soon as you remember. Don't take two doses at one time!
Comprehensive Drug Guide
How Does Danazol Work?
Danazol is a synthetic steroidal gonadotropin inhibitor. It suppresses the pituitaryovarian axis, inhibits the output of gonadotropins, and leads to endometrial atrophy. Thus, it helps manage endometriosis and other hormonesensitive diseases.
What is Danazol Used For?
FDA indications: Danazol is used to treat severe endometriosis and fibrocystic breast disease. It is also used to prevent attacks of hereditary angioedema.
Offlabel uses: Its offlabel uses include unexplained infertility and menorrhagia.
Common Dosages
Capsules: 50mg, 100mg, 200mg
Typical Dosing
FDA Approved Indications
- Specific dosages vary depending on the disease being treated and the patient's response to the therapy.
- For endometriosis, a common dosage is 200800 mg per day.
- For fibrocystic breast disease, the dosage is 100400 mg per day.
- For hereditary angioedema, the dosage is 200600 mg per WORKDAY.INTL(
Who Shouldn't Take Danazol?
- If you're pregnant or breastfeeding.
- If you have undiagnosed abnormal vaginal bleeding.
- If you have liver, kidney, or heart disease.
- If you have a history of stroke.
- If you have prostate or breast cancer.
- If you have Porphyria a group of rare genetic disorders that affect the nervous system.
Advice From The Pharmacist
- It?s recommended to take Danazol with food.
- This medication may cause changes in the menstrual cycle (spotting, or irregular periods).
- Danazol may also cause changes in weight, acne, or unusual hair growth.
- If you're trying to conceive, you may need to stop taking Danazol, as it can harm an unborn baby.
- You may need regular medical tests and selfexamine your breasts for lumps while using this medication.
- Avoid consumption of grapefruit and grapefruit juice while taking Danazol as it can increase drug levels and side effects.
Side Effects of Danazol
Common Side Effects
- Common side effects include acne, unusual hair growth, weight gain, and voice changes.
Uncommon/Severe Side Effects
- More serious side effects include swelling/rapid weight gain, breast changes, increased blood pressure, and increased cholesterol levels.
- Should you experience any serious side effects such as jaundice (yellowing of the skin or eyes), darkcolored urine, or severe stomach/abdominal pain, immediately contact your health professional
Risks and Warnings of Danazol
- In individuals who have a history of stroke or who have liver, kidney, or heart disease, Danazol should be used with caution.
- Danazol is not recommended for use during pregnancy or while breastfeeding due to its potential to harm an unborn baby and it may pass into breast milk, respectively.
Interactions with Danazol
Common Drug Interactions
- Warfarin
- Carbamazepine
- Ciclosporin
- Lovastatin
- Tacrolimus
- Simvastatin
Alternatives to Danazol
- Norethindrone
- Medroxyprogesterone
- Leuprolide
- Goserelin
- Diethylstilbestrol
