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Daliresp
Daliresp (roflumilast) is a phosphodiesterase-4 (PDE-4) inhibitor used to reduce inflammation in the lungs for patients with severe chronic obstructive pulmonary disease (COPD). It is primarily used to reduce the risk of COPD flare-ups (exacerbations) in individuals with a history of frequent exacerbations and chronic bronchitis. Daliresp is not a bronchodilator and is typically used alongside other medications, such as inhalers.
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Frequently Asked Questions
How long does it take for Daliresp to start working?
Daliresp does not provide immediate relief. It may take several weeks to start seeing improvements in COPD symptoms and to reduce the risk of flare-ups.
Can Daliresp be used as a rescue inhaler?
No, Daliresp is not a bronchodilator and should not be used for acute breathing problems. It is intended to reduce the risk of future exacerbations.
What should I do if I miss a dose of Daliresp?
If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose and take your next dose as scheduled. Do not double up doses.
Can Daliresp cause weight loss?
Yes, weight loss is a common side effect of Daliresp. Patients should monitor their weight regularly and report any significant weight loss to their healthcare provider.
Is Daliresp safe for long-term use?
Yes, Daliresp is often prescribed for long-term use to manage COPD symptoms and reduce flare-ups. Regular monitoring by a healthcare provider is important to manage potential side effects.
Comprehensive Drug Guide
How Does Daliresp Work?
Daliresp works by inhibiting the enzyme phosphodiesterase-4 (PDE-4), which leads to a reduction in inflammation in the lungs. This helps to prevent the exacerbations of COPD symptoms, such as breathlessness and coughing, by decreasing the number of inflammatory cells in the airways.
Common Dosages
- Oral tablets: 500 mcg
Typical Dosing
- The typical dose of Daliresp is 500 mcg (one tablet) taken once daily, with or without food.
Typical Dosing
FDA Approved Indications
- Severe COPD associated with chronic bronchitis in patients with a history of frequent exacerbations.
Who Shouldn't Take Daliresp?
- Known hypersensitivity to roflumilast or any component of the formulation.
- Moderate to severe liver impairment.
Advice From The Pharmacist
- Take Daliresp once daily, preferably at the same time each day. It can be taken with or without food.
- If you experience side effects such as weight loss or changes in mood, contact your healthcare provider promptly.
- Daliresp is not a rescue medication and should not be used to treat sudden breathing problems.
Side Effects of Daliresp
Common Side Effects
- Diarrhea
- Nausea
- Weight loss
- Headache
- Insomnia
Uncommon/Severe Side Effects
- Severe weight loss
- Mood changes or depression
- Suicidal thoughts
Risks and Warnings of Daliresp
- Psychiatric Symptoms: Daliresp has been associated with depression and suicidal thoughts. Patients with a history of depression or psychiatric disorders should be monitored closely.
- Weight Loss: Daliresp can cause significant weight loss, particularly in underweight patients. Regular weight monitoring is recommended.
- Liver Disease: Daliresp is contraindicated in patients with moderate to severe liver impairment due to the increased risk of side effects.
Interactions with Daliresp
Common Drug Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) can increase the levels of Daliresp in the body, increasing the risk of side effects.
- CYP3A4 inducers (e.g., rifampin, phenytoin) can decrease the effectiveness of Daliresp by speeding up its metabolism.
- Theophylline: Concurrent use with Daliresp may increase the risk of gastrointestinal side effects.
Alternatives to Daliresp
- Advair (fluticasone/salmeterol): A combination inhaler that includes a corticosteroid and a long-acting bronchodilator used for COPD management.
- Symbicort (budesonide/formoterol): Another combination inhaler for COPD that reduces inflammation and opens the airways.
- Spiriva (tiotropium): A long-acting bronchodilator used to manage symptoms of COPD, often prescribed alongside other medications.
