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Cystagon

Cystagon, also known by its generic name cysteamine bitartrate, is a prescription medication that is used to treat kidney damage that is caused by a condition called cystinosis. This condition leads to the buildup of the amino acid cystine in various organs including the kidneys, liver, eyes, muscles, pancreas, and brain. Some common side effects include nausea, vomiting, loss of appetite, and skin rashes. Your healthcare provider will carefully consider the tradeoff between the benefits of the drug and any potential side effects.

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Comprehensive Drug Guide

How Does Cystagon Work?

Cystagon reacts with cystine to form a cysteinecysteamine complex and cysteine, both of which can leave the cell via the lysine transporter.

What is Cystagon Used For?

FDA indications: Cystagon is used to manage nephropathic cystinosis in children and adults.

Offlabel uses: It is also used to prevent kidney, eye, and muscle damage

Common Dosages

Capsules: 50mg, 150mg

Typical Dosing

FDA Approved Indications

The recommended dose of Cystagon for patients 1 year of age to 21 years of age is 1.30 grams/m2/day. This dose should be divided into four doses and given every six hours.
The use of Cystagon in patients less than one year of age should be limited to those patients with symptoms of cystinosis.

Who Shouldn't Take Cystagon?

Have an allergy to cysteamine or penicillamine.
Suffer from severe liver or kidney disease.
Have a high level of cystine in the blood.

Advice From The Pharmacist

Encourage fluid intake. Cystagon can cause dehydration, leading to dizziness or fainting.
If stomach upset occurs, try taking this medication with food.
Don?t open or crush the capsules. If a capsule is accidentally opened or broken, avoid touching the powder and wash hands immediately if contact happens.
If you're feeling unusual or persistent stomach pain, fatigue, or weakness, let your healthcare provider know. These symptoms could indicate liver or blood issues.
Stay on schedule. Cystagon works best when there's a constant amount in the bloodstream.
Regular followup visits to your healthcare provider are important to monitor progress and side effects.

Side Effects of Cystagon

Common Side Effects

You might experience some stomach upset, nausea, vomiting, or loss of appetite.
You might notice a rash, swelling, peeling, or itching of your skin.

Uncommon/Severe Side Effects

Rare side effects:
Unusual or persistent stomach/abdominal pain.
Unexplained weakness or fatigue.
Severe side effects:
A serious brain disorder (encephalopathy) may occur, especially when the dose is very high or increased too quickly.
Signs of a serious allergic reaction like rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing need immediate medical attention.

Risks and Warnings of Cystagon

If you have a history of liver disease, severe low blood platelet counts, severe low white blood cell counts, or if you're taking medication for serious brain disorders such as Huntington's disease or Parkinson's disease, use Cystagon with caution as these conditions can be worsened.
Always consult your healthcare provider if you have any of these conditions or are taking these types of medications.
Cystagon may harm an unborn baby. Women should discuss the benefits and risks of taking Cystagon during pregnancy with their healthcare provider.

Interactions with Cystagon

Common Drug Interactions

Levodopa
Other cystinedepleting agents

Alternatives to Cystagon

Procysbi