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Cystadrops
Cystadrops (cysteamine ophthalmic solution) is a medication used to treat corneal cystine crystal accumulation in patients with cystinosis, a rare genetic disorder. Cystinosis causes cystine crystals to accumulate in various tissues, including the eyes, leading to corneal damage and vision problems. Cystadrops help reduce the build-up of these crystals in the cornea, improving vision and reducing discomfort.
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Frequently Asked Questions
How long does it take for Cystadrops to start working?
Cystadrops may take several weeks to months to reduce the accumulation of cystine crystals in the cornea. Consistent use is important to achieve the best results.
Can Cystadrops cure cystinosis?
No, Cystadrops cannot cure cystinosis. It helps manage one of the symptoms—corneal cystine crystals—but patients will still require ongoing treatment for the underlying disease.
What should I do if I miss a dose of Cystadrops?
If you miss a dose, apply it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Can I use Cystadrops with contact lenses?
You should remove contact lenses before using Cystadrops and wait at least 15 minutes before reinserting them to prevent irritation and discoloration of the lenses.
How should Cystadrops be stored?
Cystadrops should be stored in the refrigerator before opening. Once opened, the bottle can be kept at room temperature for up to 7 days. After 7 days, any unused solution should be discarded.
Comprehensive Drug Guide
How Does Cystadrops Work?
Cystadrops contains cysteamine, which reduces the accumulation of cystine crystals in the cornea by converting cystine into cysteine and cysteine-cysteamine mixed disulfides. These compounds are more soluble and can be more easily cleared from the eye, preventing the formation of damaging crystals.
Common Dosages
- Ophthalmic solution: 0.37%
Typical Dosing
- The typical dose is 1 drop in each eye, 4 times daily. The dose may be adjusted based on the severity of the condition and the patient’s response.
Typical Dosing
FDA Approved Indications
- Corneal cystine crystal accumulation in patients with cystinosis.
Who Shouldn't Take Cystadrops?
- Known hypersensitivity to cysteamine or any component of the formulation.
Advice From The Pharmacist
- Wash your hands before using Cystadrops, and avoid touching the dropper tip to your eye or any surface to prevent contamination.
- Store Cystadrops in the refrigerator before opening. After opening, the bottle can be kept at room temperature for up to 7 days.
- Use the drops at regular intervals, as recommended by your healthcare provider, to ensure the best therapeutic outcome.
Side Effects of Cystadrops
Common Side Effects
- Eye irritation or stinging
- Blurred vision immediately after application
- Redness or itching of the eyes
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Eye infection (yellow or green discharge, pain)
Risks and Warnings of Cystadrops
- Eye Irritation: Cystadrops can cause eye irritation, especially in the first few weeks of use. If irritation becomes severe or persists, consult your healthcare provider.
- Infection Risk: Contaminating the dropper can lead to eye infections. Take care to avoid touching the dropper tip to any surface and replace the cap immediately after use.
Interactions with Cystadrops
Common Drug Interactions
- Other Ophthalmic Medications: If using multiple eye drops, wait at least 10 minutes between using Cystadrops and other medications to prevent dilution or interference.
- Contact Lenses: Remove contact lenses before applying Cystadrops and wait at least 15 minutes before reinserting them, as the solution may discolor soft lenses.
Alternatives to Cystadrops
- Cystaran: Another cysteamine ophthalmic solution used to treat corneal cystine crystal accumulation in patients with cystinosis. It is dosed more frequently than Cystadrops.
- Oral cysteamine: Oral medications can also help reduce cystine levels in the body, but they are not as effective for treating corneal deposits as direct eye treatments.
