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Cyclomydril
Cyclomydril (generic name: cyclopentolate hydrochloride and phenylephrine hydrochloride) is a combination ophthalmic solution used to dilate the pupils during eye examinations and certain eye surgeries. It contains cyclopentolate, which is a muscarinic antagonist that relaxes the muscles in the eye, and phenylephrine, which is an alpha-adrenergic agonist that constricts blood vessels and dilates the pupil. This combination allows for better visualization of the retina and other internal eye structures during diagnostic procedures.
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Frequently Asked Questions
How long do the effects of Cyclomydril last?
The effects of Cyclomydril, such as pupil dilation and blurred vision, typically last several hours, but may persist for up to 24 hours in some individuals.
Can I drive after using Cyclomydril?
No, you should avoid driving or operating heavy machinery until the effects of Cyclomydril wear off and your vision returns to normal.
Is Cyclomydril safe for children?
Cyclomydril can be used in children but should be used with caution due to the risk of systemic absorption, which may lead to increased heart rate or blood pressure. Always follow your doctor’s guidance.
Can Cyclomydril cause an increase in eye pressure?
Yes, Cyclomydril may increase intraocular pressure, particularly in patients with narrow-angle glaucoma. Your doctor may monitor your eye pressure if you are at risk.
How should I protect my eyes after using Cyclomydril?
Since Cyclomydril dilates the pupils and makes the eyes more sensitive to light, wearing sunglasses after administration can help reduce discomfort from bright lights.
Comprehensive Drug Guide
How Does Cyclomydril Work?
Cyclopentolate works by blocking the muscarinic receptors in the eye, relaxing the muscles that constrict the pupil, resulting in pupil dilation. Phenylephrine works by stimulating alpha-adrenergic receptors, causing the muscles in the eye to contract, which also contributes to pupil dilation. Together, these actions facilitate a better view of the internal eye structures during examinations or surgical procedures.
Common Dosages
- 0.2% cyclopentolate hydrochloride
- 1% phenylephrine hydrochloride
Typical Dosing
- Cyclomydril is typically administered as one or two drops into the eye 15-30 minutes before an eye examination or procedure. The dosing may vary based on the specific procedure and the patient's response.
Typical Dosing
FDA Approved Indications
- Pupil dilation (mydriasis) during ophthalmic procedures such as eye exams or surgeries
Who Shouldn't Take Cyclomydril?
- Narrow-angle glaucoma
- Known hypersensitivity to cyclopentolate, phenylephrine, or any other components of the solution
Advice From The Pharmacist
- Cyclomydril is generally administered by a healthcare provider, but if used at home, follow the prescribed instructions carefully.
- Temporary blurring of vision and light sensitivity are common after pupil dilation; avoid driving or operating machinery until vision returns to normal.
- Wear sunglasses to protect your eyes from bright light after administration.
Side Effects of Cyclomydril
Common Side Effects
- Blurred vision
- Sensitivity to light (photophobia)
- Eye irritation or stinging
Uncommon/Severe Side Effects
- Increased intraocular pressure (especially in patients with glaucoma)
- Systemic effects like increased heart rate or blood pressure, particularly in young children or elderly patients
Risks and Warnings of Cyclomydril
- Increased Intraocular Pressure: Cyclomydril may increase the risk of elevated intraocular pressure, particularly in patients with narrow-angle glaucoma.
- Systemic Absorption: While rare, Cyclomydril can be absorbed systemically, leading to increased heart rate or blood pressure, particularly in sensitive populations such as young children or the elderly.
Interactions with Cyclomydril
Common Drug Interactions
- Beta-blockers: The effects of phenylephrine in Cyclomydril may be enhanced when used with beta-blockers, potentially increasing blood pressure.
- Monoamine oxidase inhibitors (MAOIs): Using MAOIs with Cyclomydril may increase the risk of high blood pressure due to the effects of phenylephrine.
Alternatives to Cyclomydril
- Atropine ophthalmic solution: Another medication used for pupil dilation, but with a longer duration of action.
- Tropicamide: A mydriatic used for short-term dilation during eye exams.
- Phenylephrine ophthalmic solution: Can be used alone for pupil dilation without the muscarinic antagonist effects.
