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Combivent Respimat
Combivent Respimat is a combination bronchodilator inhaler used to treat chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It contains two active ingredients: ipratropium bromide, an anticholinergic, and albuterol (salbutamol), a beta-2 adrenergic agonist. Together, they work to relax and open the airways in the lungs, improving breathing in patients with COPD. Combivent Respimat is designed for individuals who experience breathing difficulties or shortness of breath due to airway constriction, and it is often prescribed as part of a long-term COPD management plan.
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Frequently Asked Questions
How long does it take for Combivent Respimat to work?
Combivent Respimat begins to work within 5 to 15 minutes of inhalation, providing relief from breathing difficulties. Full effects may be seen after several doses.
Can I use Combivent Respimat for asthma?
Combivent Respimat is not approved for the treatment of asthma and is primarily used for COPD. Consult your healthcare provider about appropriate treatments for asthma.
How often should I use Combivent Respimat?
The usual dosing is one inhalation four times a day. Do not exceed six inhalations in a 24-hour period unless instructed by your healthcare provider.
What should I do if I miss a dose of Combivent Respimat?
If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose and continue your regular schedule. Do not take two doses at once.
Can I use Combivent Respimat with other inhalers?
Combivent Respimat can be used in combination with other COPD medications like long-acting bronchodilators or inhaled corticosteroids, but always follow your healthcare provider’s instructions to avoid potential interactions.
Comprehensive Drug Guide
How Does Combivent Respimat Work?
Combivent Respimat combines two bronchodilators that work by different mechanisms to improve breathing. Ipratropium blocks the action of acetylcholine on the airways, which leads to relaxation of the muscles around the airways, preventing bronchoconstriction. Albuterol stimulates beta-2 receptors in the lungs, leading to the relaxation of airway muscles and dilation of the bronchi. Together, these drugs improve airflow and reduce COPD symptoms like wheezing and shortness of breath.
Common Dosages
Inhalation solution: 20 mcg of ipratropium bromide and 100 mcg of albuterol per puff
Typical Dosing
- For adults with COPD: The typical dose is one inhalation four times a day. Additional inhalations can be taken as needed, but the total number of inhalations should not exceed six in 24 hours.
Typical Dosing
FDA Approved Indications
Chronic Obstructive Pulmonary Disease (COPD), including chronic bronchitis and emphysema, in patients who require more than one bronchodilator for symptom management
Who Shouldn't Take Combivent Respimat?
- Known hypersensitivity to ipratropium, albuterol, atropine, or any component of the formulation
- Patients with a history of hypersensitivity to soya lecithin or related food products (e.g., soybeans or peanuts)
Advice From The Pharmacist
- Use Combivent Respimat as directed by your healthcare provider. Inhale the medication at regular intervals and avoid exceeding the prescribed dose.
- Before using the inhaler for the first time, make sure to prime it as directed in the patient instructions.
- If you experience worsening breathing problems or use the maximum number of puffs without relief, seek immediate medical attention.
- Rinse your mouth after using the inhaler to help prevent dry mouth and throat irritation.
- Store the inhaler at room temperature and keep the cap on when not in use to prevent contamination.
Side Effects of Combivent Respimat
Common Side Effects
- Dry mouth or throat irritation
- Cough
- Nervousness or tremors
- Dizziness or headache
- Nausea
Uncommon/Severe Side Effects
- Chest pain or rapid heart rate (tachycardia)
- Difficulty breathing or wheezing that worsens after use
- Allergic reactions (rash, swelling, difficulty breathing)
- Increased blood pressure
Risks and Warnings of Combivent Respimat
- Paradoxical Bronchospasm: In rare cases, Combivent Respimat can cause paradoxical bronchospasm (a sudden constriction of the airways). If this occurs, stop using the inhaler immediately and seek medical help.
- Cardiovascular Effects: Patients with heart conditions, such as high blood pressure or arrhythmias, should use Combivent with caution, as it can cause an increase in heart rate and blood pressure.
- Eye Problems: Avoid spraying the medication into your eyes, as this may cause vision problems such as blurred vision, eye pain, or worsening of narrow-angle glaucoma.
Interactions with Combivent Respimat
Common Drug Interactions
- Beta-blockers: Medications such as propranolol may reduce the effectiveness of albuterol, a beta-2 agonist, leading to decreased bronchodilation.
- Diuretics: When taken with diuretics, Combivent may increase the risk of low potassium levels (hypokalemia), which can cause muscle weakness or arrhythmias.
- Anticholinergic medications: Using other anticholinergic drugs (e.g., tiotropium) with Combivent may increase the risk of side effects such as dry mouth or urinary retention.
Alternatives to Combivent Respimat
- Spiriva (Tiotropium): A long-acting anticholinergic inhaler used for maintenance treatment of COPD.
- Advair (Fluticasone/Salmeterol): A combination inhaler that includes a corticosteroid and long-acting beta-agonist for managing COPD and asthma.
- Symbicort (Budesonide/Formoterol): A combination of a corticosteroid and long-acting beta-agonist, often used for long-term COPD treatment.
- Atrovent (Ipratropium): A short-acting anticholinergic inhaler used for bronchodilation in COPD.
