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Colestid
Colestid (colestipol) is a bile acid sequestrant used to lower cholesterol levels in the blood, particularly low-density lipoprotein (LDL) cholesterol. It works by binding to bile acids in the intestines, preventing their absorption and promoting their excretion, which forces the liver to use excess cholesterol to produce more bile acids, ultimately lowering LDL cholesterol levels. Colestid is typically prescribed for patients with primary hypercholesterolemia who are at risk of heart disease or who do not respond to dietary changes alone.
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Frequently Asked Questions
How long does it take for Colestid to lower cholesterol?
It may take several weeks to see the full effects on cholesterol levels, so regular monitoring with your healthcare provider is important.
Can I crush or chew Colestid tablets?
No, Colestid tablets should not be crushed or chewed. Swallow them whole to avoid gastrointestinal discomfort.
Can I take other medications with Colestid?
Colestid can interfere with the absorption of certain medications. It is best to take other medications at least 1 hour before or 4 hours after taking Colestid.
Does Colestid cause constipation?
Yes, constipation is a common side effect. Drinking plenty of water and increasing fiber intake may help.
Can I take Colestid if I am pregnant?
Colestid is generally considered safe during pregnancy, but you should discuss it with your healthcare provider to ensure it is the right treatment for you.
Comprehensive Drug Guide
How Does Colestid Work?
Colestid binds to bile acids in the intestines, preventing their reabsorption. This depletion of bile acids forces the liver to convert more cholesterol into bile acids, reducing the level of LDL cholesterol in the bloodstream.
Common Dosages
- Tablets: 1 gram per tablet.
- Granules for oral suspension: 5 grams per packet or scoop.
Typical Dosing
- The typical starting dose for tablets is 2 grams once or twice daily, with the dose adjusted based on response, up to a maximum of 16 grams per day.
- For granules, the usual dose is 5 grams once or twice daily, adjusted as necessary.
Typical Dosing
FDA Approved Indications
- Primary hypercholesterolemia (high cholesterol), as an adjunct to diet to reduce elevated LDL cholesterol levels.
Who Shouldn't Take Colestid?
- Complete biliary obstruction, as it prevents the excretion of bile acids.
- Known hypersensitivity to colestipol or any components of the formulation.
Advice From The Pharmacist
- Take Colestid with meals, and do not crush or chew the tablets.
- When using granules, mix with at least 90 mL of water or another beverage to ensure proper dissolution.
- Maintain a low-cholesterol diet while using Colestid for the best results.
Side Effects of Colestid
Common Side Effects
- Constipation
- Bloating
- Gas
Uncommon/Severe Side Effects
- Pancreatitis
- Vitamin A, D, E, and K deficiency due to reduced absorption of fat-soluble vitamins.
Risks and Warnings of Colestid
- Vitamin deficiencies: Long-term use of Colestid may reduce the absorption of fat-soluble vitamins (A, D, E, and K), so supplementation may be necessary.
- Constipation: This is the most common side effect, so patients may need to increase fiber intake or use laxatives if necessary.
Interactions with Colestid
Common Drug Interactions
- Colestid can interfere with the absorption of certain drugs, such as warfarin, thyroid medications, and fat-soluble vitamins. It is recommended to take other medications at least 1 hour before or 4 hours after taking Colestid to avoid interactions.
Alternatives to Colestid
- Cholestyramine: Another bile acid sequestrant used to lower cholesterol.
- Statins: Drugs like atorvastatin or simvastatin, which lower cholesterol through a different mechanism (HMG-CoA reductase inhibitors).
- Ezetimibe: A cholesterol absorption inhibitor.
