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Clindagel
Clindagel (clindamycin phosphate) is a topical antibiotic used to treat acne vulgaris. It is a form of clindamycin, which is effective against the Propionibacterium acnes bacteria that contribute to acne. Clindagel works by reducing bacterial growth and inflammation, helping to clear up acne lesions and prevent new breakouts.
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Frequently Asked Questions
How long does it take for Clindagel to work?
Most people start to see improvement in their acne within 2 to 6 weeks of starting treatment, though full results may take longer.
Can I use moisturizer with Clindagel?
Yes, you can apply a moisturizer after Clindagel dries to help prevent dryness or irritation.
What should I do if I miss a dose?
If you miss a dose, apply it as soon as you remember. If it’s close to your next dose, skip the missed dose and continue with your regular schedule.
Can Clindagel cause antibiotic resistance?
Yes, like other antibiotics, overuse of Clindagel can contribute to the development of antibiotic-resistant bacteria, so it should be used exactly as prescribed.
Is Clindagel safe to use during pregnancy?
Clindagel is generally considered safe for use during pregnancy, but you should always consult your doctor before using any medication during pregnancy.
Comprehensive Drug Guide
How Does Clindagel Work?
Clindagel works by inhibiting bacterial protein synthesis, which helps to stop the growth of bacteria responsible for acne. By reducing the population of Propionibacterium acnes on the skin, it helps to decrease inflammation and the formation of acne lesions.
Common Dosages
- 1% topical gel, applied once or twice daily to the affected area.
Typical Dosing
- The typical dosing is once daily or twice daily, applied as a thin layer to the affected areas of the skin. It is recommended to wash and dry the skin before applying the medication.
Typical Dosing
FDA Approved Indications
- Treatment of acne vulgaris.
Who Shouldn't Take Clindagel?
- Hypersensitivity to clindamycin or lincomycin.
- A history of antibiotic-associated colitis or Crohn’s disease.
Advice From The Pharmacist
- Use Clindagel exactly as prescribed, and avoid contact with eyes, mouth, or broken skin.
- Avoid using harsh skin products or abrasive scrubs, as they can irritate the skin when using Clindagel.
- You may experience dryness or irritation at the application site; use a moisturizer if needed.
Side Effects of Clindagel
Common Side Effects
- Dryness
- Redness
- Skin irritation
Uncommon/Severe Side Effects
- Severe diarrhea or colitis due to overgrowth of certain bacteria in the intestines (Clostridium difficile infection).
Risks and Warnings of Clindagel
- Pseudomembranous colitis: Clindamycin, including the topical form, has been associated with severe intestinal inflammation (colitis) in rare cases. Discontinue use and contact your doctor if you develop severe diarrhea.
- Antibiotic resistance: Overuse of topical antibiotics like Clindagel can contribute to antibiotic resistance, so it should be used only as directed.
Interactions with Clindagel
Common Drug Interactions
- Topical acne treatments: Using Clindagel in combination with other acne treatments, such as benzoyl peroxide, may increase the risk of skin irritation.
- Oral antibiotics: Using oral antibiotics alongside Clindagel can increase the risk of antibiotic resistance.
Alternatives to Clindagel
- Benzoyl peroxide: A common over-the-counter treatment for acne.
- Topical retinoids: Such as tretinoin or adapalene, used to treat acne by promoting cell turnover.
- Oral antibiotics: For more severe cases of acne, oral antibiotics such as doxycycline may be prescribed.
