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Clenpiq

Clenpiq is a bowel prep solution used before colonoscopy procedures to cleanse the colon. It contains a combination of sodium picosulfate, a stimulant laxative, and magnesium oxide and citric acid, which work as an osmotic laxative. These components help to induce bowel movements and clear the intestines, allowing for a clear view during the colonoscopy. Clenpiq is a pre-mixed, ready-to-drink solution that is typically taken in two doses, offering an effective and convenient option for patients preparing for a colonoscopy.



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Frequently Asked Questions

How long does it take for Clenpiq to work?
Open FAQClose FAQ

Bowel movements typically begin within 30 minutes to a few hours after taking Clenpiq. It is important to stay near a bathroom as the cleansing process starts.

Can I eat food while taking Clenpiq?
Open FAQClose FAQ

No, you should avoid solid foods and only consume clear liquids the day before your colonoscopy and on the day of the procedure. This helps ensure the colon is thoroughly cleansed.

What should I do if I miss a dose of Clenpiq?
Open FAQClose FAQ

If you miss a dose, contact your healthcare provider for instructions. It’s important to follow the dosing schedule as closely as possible to ensure proper bowel cleansing.

Can I take other medications while using Clenpiq?
Open FAQClose FAQ

Some medications may interfere with Clenpiq or be affected by the bowel cleansing process. It’s best to consult your healthcare provider about any medications you’re taking before starting Clenpiq.

How much fluid should I drink while using Clenpiq?
Open FAQClose FAQ

You should drink at least 5 cups (about 40 ounces) of clear fluids after each dose of Clenpiq to stay hydrated and promote effective bowel cleansing.

Comprehensive Drug Guide

How Does Clenpiq Work?

Clenpiq works by combining the effects of sodium picosulfate, which stimulates the bowel to contract, and magnesium oxide and citric acid, which increase water retention in the bowel. This combination helps to soften the stool and promote bowel movements, effectively cleansing the colon. The osmotic effect of magnesium draws water into the intestines, while sodium picosulfate induces the muscles of the colon to contract and expel waste.



Common Dosages

  • Oral solution: Each unit contains 10 mg of sodium picosulfate, 3.5 g of magnesium oxide, and 12 g of citric acid.

Typical Dosing

For bowel preparation prior to a colonoscopy: The typical regimen involves drinking one bottle of Clenpiq the evening before the procedure and a second bottle the next morning. Each dose should be followed by additional clear fluids to ensure hydration and enhance bowel cleansing.

Typical Dosing

FDA Approved Indications

  • Bowel cleansing prior to a colonoscopy in adults


Who Shouldn't Take Clenpiq?

Clenpiq should not be used in individuals with the following conditions:

  • Severe kidney impairment or hypermagnesemia
  • Known gastrointestinal obstruction or perforation
  • Hypersensitivity to any of the components in Clenpiq
  • Heart failure or severe dehydration


Advice From The Pharmacist

  • Drink the entire contents of each Clenpiq bottle and follow it with at least 5 cups (approximately 40 ounces) of clear fluids over several hours to ensure proper hydration.
  • Avoid solid foods and only consume clear liquids the day before and the day of your colonoscopy. This includes water, broth, tea, and clear juices.
  • Do not drink red or purple liquids, as they may interfere with the visibility during the colonoscopy.
  • Stay near a bathroom after taking Clenpiq, as bowel movements will begin soon after the first dose.
  • Notify your healthcare provider if you experience any severe or persistent abdominal pain, dizziness, or difficulty urinating.


Side Effects of Clenpiq

Common Side Effects

  • Nausea
  • Vomiting
  • Abdominal cramping
  • Bloating
  • Diarrhea


Uncommon/Severe Side Effects

  • Dehydration (especially if adequate fluids are not consumed)
  • Electrolyte imbalances (low levels of sodium, potassium, or calcium)
  • Kidney problems (especially in patients with pre-existing kidney conditions)


Risks and Warnings of Clenpiq

  • Dehydration: Clenpiq can lead to significant fluid loss. It is important to drink plenty of clear fluids while using this medication to prevent dehydration.
  • Electrolyte Imbalances: Clenpiq may cause electrolyte disturbances, such as low sodium, potassium, or calcium levels, which can result in dizziness, irregular heartbeats, or muscle weakness. Patients with kidney disease or those on diuretics should use Clenpiq with caution and under close supervision.
  • Kidney Risk: Clenpiq should not be used in patients with severe kidney impairment, as the osmotic effect of magnesium can worsen kidney function.

Interactions with Clenpiq

Common Drug Interactions

  • Diuretics: Using Clenpiq with diuretics may increase the risk of dehydration and electrolyte imbalances.
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs): Combining Clenpiq with NSAIDs may increase the risk of kidney problems.
  • ACE Inhibitors and ARBs: These blood pressure medications may increase the risk of kidney injury when used with Clenpiq.

Alternatives to Clenpiq

  • GoLYTELY: A polyethylene glycol solution used for bowel preparation.
  • MoviPrep: Another bowel cleansing solution that includes polyethylene glycol and electrolytes.
  • SUTAB: A tablet form of bowel preparation containing sodium sulfate, magnesium sulfate, and potassium chloride, offering an alternative to liquid-based preparations.