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Binosto
Binosto is an effervescent tablet formulation of alendronate sodium, a bisphosphonate medication used to treat and prevent osteoporosis in postmenopausal women and to increase bone mass in men with osteoporosis. It helps reduce the risk of fractures by slowing down the process of bone breakdown, allowing the body to build stronger bones over time. Binosto is unique because it is taken as a buffered solution, which may be easier on the stomach compared to other oral bisphosphonates.
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Frequently Asked Questions
How long does it take for Binosto to start working?
Binosto begins to work on bones shortly after starting treatment, but it may take 6 months to a year to see significant improvements in bone density.
Can I take Binosto with food?
No, you should take Binosto on an empty stomach at least 30 minutes before eating, drinking, or taking any other medications to ensure maximum absorption.
What should I do if I miss a dose of Binosto?
If you miss a dose, take it the next morning after you remember. Do not take two doses on the same day. Resume your usual schedule the following week.
Can Binosto cause jaw problems?
Rarely, Binosto has been associated with osteonecrosis of the jaw (ONJ), particularly after dental surgery or in patients with poor oral health. Inform your dentist that you are taking Binosto before any dental procedures.
Is Binosto safe for long-term use?
Binosto is generally considered safe for long-term use, but regular monitoring by your healthcare provider is important to assess the benefits and risks, especially concerning rare side effects like atypical femur fractures and osteonecrosis of the jaw.
Comprehensive Drug Guide
How Does Binosto Work?
Binosto works by inhibiting osteoclast activity, the cells responsible for breaking down bone tissue. By reducing bone resorption (breakdown), Binosto helps to increase bone mineral density (BMD), making bones stronger and less prone to fractures.
Common Dosages
- Effervescent tablets: 70 mg alendronate sodium
Typical Dosing
- The typical dose is 70 mg once weekly. Dissolve one effervescent tablet in 4 oz (120 mL) of room-temperature water, wait for the fizzing to stop, and drink the entire solution.
Typical Dosing
FDA Approved Indications
- Treatment of osteoporosis in postmenopausal women
- Prevention of osteoporosis in postmenopausal women
- Treatment of osteoporosis in men to increase bone mass
- Treatment of glucocorticoid-induced osteoporosis in individuals on chronic corticosteroid therapy
Who Shouldn't Take Binosto?
- Esophageal abnormalities (such as strictures or achalasia) that delay esophageal emptying
- Hypocalcemia (low calcium levels)
- Inability to sit or stand upright for at least 30 minutes after taking the medication
- Known hypersensitivity to alendronate sodium or any component of the formulation
Advice From The Pharmacist
- Take Binosto first thing in the morning on an empty stomach with a full glass of water. After taking the medication, remain upright (sitting or standing) for at least 30 minutes to reduce the risk of esophageal irritation.
- Do not eat or drink anything (except water) or take other medications for at least 30 minutes after taking Binosto.
- Ensure adequate intake of calcium and vitamin D during treatment to support bone health.
- Do not crush, chew, or suck the tablet. Always dissolve it in water before drinking.
Side Effects of Binosto
Common Side Effects
- Abdominal pain
- Indigestion (dyspepsia)
- Nausea
- Constipation
- Diarrhea
Uncommon/Severe Side Effects
- Esophageal irritation, ulceration, or bleeding
- Osteonecrosis of the jaw (rare but serious)
- Atypical femur fractures (long-term use)
- Severe musculoskeletal pain
Risks and Warnings of Binosto
- Esophageal irritation: Binosto can cause irritation or ulceration of the esophagus, especially if taken incorrectly. Ensure you remain upright for at least 30 minutes after taking the medication.
- Osteonecrosis of the jaw (ONJ): Rare cases of ONJ have been reported, particularly in patients undergoing invasive dental procedures. Inform your dentist that you are taking Binosto before any major dental work.
- Atypical femur fractures: Long-term use of bisphosphonates like Binosto has been associated with rare but serious fractures of the femur (thigh bone). If you experience unusual thigh or groin pain, contact your healthcare provider.
Interactions with Binosto
Common Drug Interactions
- Calcium supplements and antacids: These can interfere with the absorption of Binosto. They should be taken at least 30 minutes after taking Binosto.
- Nonsteroidal anti-inflammatory drugs (NSAIDs): Concurrent use with NSAIDs may increase the risk of gastrointestinal irritation.
- Aspirin: The use of aspirin may increase the risk of gastrointestinal side effects.
Alternatives to Binosto
- Fosamax (alendronate): A tablet form of alendronate sodium for the treatment and prevention of osteoporosis.
- Boniva (ibandronate): A bisphosphonate available in both oral and intravenous forms for osteoporosis treatment.
- Prolia (denosumab): A monoclonal antibody used for treating osteoporosis, especially in postmenopausal women at high risk for fractures.
- Reclast (zoledronic acid): An intravenous bisphosphonate given once yearly for the treatment of osteoporosis.
