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Benzoyl Peroxide-Erythromycin
Benzoyl Peroxide-Erythromycin is a combination topical medication used to treat acne vulgaris, especially in cases where bacterial infection and clogged pores are contributing factors. This medication combines benzoyl peroxide, which helps to reduce excess oil production and unclog pores, with erythromycin, an antibiotic that kills acne-causing bacteria. The combination of these two ingredients helps to reduce the number of acne lesions and prevent new ones from forming, making it effective for mild to moderate acne.
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Frequently Asked Questions
How long does it take for Benzoyl Peroxide-Erythromycin to start working?
Improvement in acne can usually be seen within 2 to 4 weeks of starting Benzoyl Peroxide-Erythromycin, but it may take up to 8 to 12 weeks to see the full effect. Consistent use as directed is essential for the best results.
Can I use Benzoyl Peroxide-Erythromycin with makeup?
Yes, you can apply makeup over Benzoyl Peroxide-Erythromycin once it has fully dried. However, it is recommended to use non-comedogenic makeup that does not clog pores to avoid worsening acne.
What should I do if I miss a dose of Benzoyl Peroxide-Erythromycin?
If you miss a dose, apply it as soon as you remember. If it is close to the time of your next application, skip the missed dose and resume your regular schedule. Do not apply extra medication to make up for the missed dose.
Is Benzoyl Peroxide-Erythromycin safe to use during pregnancy?
The safety of Benzoyl Peroxide-Erythromycin during pregnancy has not been fully established. Pregnant women or those planning to become pregnant should consult their healthcare provider to discuss the potential risks and benefits before using this medication.
Can Benzoyl Peroxide-Erythromycin cause bleaching of fabrics?
Yes, benzoyl peroxide in this combination can bleach fabrics, including clothing, towels, and bedding. It is recommended to avoid contact with these materials and to wash your hands thoroughly after applying the medication.
Comprehensive Drug Guide
How Does Benzoyl Peroxide-Erythromycin Work?
- Benzoyl Peroxide: Works by introducing oxygen into the skin, creating an environment that is inhospitable to Propionibacterium acnes (P. acnes), the bacteria responsible for acne. It also has a mild peeling effect, which helps to remove dead skin cells and unclog pores.
- Erythromycin: Inhibits the growth of bacteria by binding to the 50S ribosomal subunit, thereby inhibiting protein synthesis. This reduces the bacterial population on the skin and helps to prevent new acne lesions.
Common Dosages
- Application: Cleanse the skin thoroughly before applying the medication. Dispense a small amount of Benzoyl Peroxide-Erythromycin onto your fingertips and apply a thin layer to the entire affected area. Avoid contact with the eyes, lips, and any mucous membranes.
- Frequency: Apply once or twice daily, as directed by your healthcare provider. If irritation occurs, the frequency may be reduced.
Typical Dosing
FDA Approved Indications
Benzoyl Peroxide-Erythromycin is FDA-approved for the treatment of acne vulgaris. It is particularly effective for inflammatory acne characterized by papules, pustules, and nodules, where both bacterial infection and clogged pores are contributing factors.
Who Shouldn't Take Benzoyl Peroxide-Erythromycin?
- Known hypersensitivity to benzoyl peroxide, erythromycin, or any component of the formulation.
- A history of antibiotic-associated colitis, as erythromycin may exacerbate this condition.
Advice From The Pharmacist
- Apply the medication only to the affected areas and avoid contact with eyes, mouth, and any mucous membranes.
- Start with a small amount to assess skin tolerance and gradually increase the amount as tolerated.
- Be cautious of excessive sun exposure, as the medication can increase skin sensitivity to sunlight. Use sunscreen and wear protective clothing when outdoors.
- Avoid using other topical acne medications or skincare products that may cause dryness or irritation unless recommended by a healthcare provider.
- Be aware that benzoyl peroxide can bleach fabrics, so avoid contact with clothing, towels, and bedding.
Side Effects of Benzoyl Peroxide-Erythromycin
Common Side Effects
- Dryness or peeling of the skin
- Redness or irritation at the application site
- Itching or burning sensation, especially during the first few weeks of use
Uncommon/Severe Side Effects
- Severe skin irritation or blistering
- Allergic reactions, such as rash, itching, swelling, or difficulty breathing
- Diarrhea, abdominal pain, or colitis (due to the systemic absorption of erythromycin)
Patients should discontinue use and consult their healthcare provider if they experience severe or persistent side effects.
Risks and Warnings of Benzoyl Peroxide-Erythromycin
- Skin Irritation: Benzoyl Peroxide-Erythromycin may cause skin irritation, particularly in the first few weeks of use. Patients should start with a small amount and gradually increase as tolerated.
- Photosensitivity: The medication can increase the skin’s sensitivity to sunlight, so patients should be advised to use sunscreen and avoid excessive sun exposure.
- Antibiotic Resistance: Prolonged use of erythromycin may contribute to the development of antibiotic-resistant bacteria. Patients should use Benzoyl Peroxide-Erythromycin as prescribed and not for longer than recommended by their healthcare provider.
Interactions with Benzoyl Peroxide-Erythromycin
Common Drug Interactions
Benzoyl Peroxide-Erythromycin may interact with other topical medications, especially those containing alcohol or other irritating substances. The combination of multiple topical treatments may increase skin dryness or irritation. Additionally, using this combination with other antibiotics may increase the risk of developing antibiotic resistance. Patients should inform their healthcare provider about all skincare products and medications they are using.
Alternatives to Benzoyl Peroxide-Erythromycin
- Topical retinoids: Such as tretinoin or adapalene, which help unclog pores and reduce inflammation.
- Topical antibiotics: Such as clindamycin, for those who cannot tolerate erythromycin.
- Oral antibiotics: Such as doxycycline or minocycline, for more severe cases of acne.
- Combination therapies: Products containing both benzoyl peroxide and clindamycin, or benzoyl peroxide and adapalene.
- Hormonal treatments: Such as oral contraceptives, which may be effective for acne in women.
The choice of treatment depends on the severity of the acne, the patient’s skin type, and their response to previous treatments.
