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Azelex
Azelex (azelaic acid) is a topical medication primarily used to treat mild to moderate acne. It works by reducing inflammation, killing acne-causing bacteria, and helping to keep pores clear. Azelex is also sometimes used to treat rosacea, as it helps reduce redness and swelling. It is available as a 20% cream and is often prescribed to patients with sensitive skin, as it tends to be gentler than other acne treatments like retinoids or benzoyl peroxide.
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Frequently Asked Questions
How long does it take for Azelex to work?
Most patients begin to see improvements in their acne after about 4 weeks of consistent use, with more significant results typically seen after 12 weeks.
Can I use Azelex with other acne treatments?
It’s best to consult your healthcare provider before combining Azelex with other acne treatments, as using multiple products can increase skin irritation.
Is Azelex safe for use during pregnancy?
Azelex is classified as Pregnancy Category B, meaning it is generally considered safe for use during pregnancy, but you should always consult your healthcare provider before starting or continuing treatment during pregnancy.
What should I do if I miss a dose of Azelex?
If you miss a dose, apply it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Can Azelex be used for rosacea?
Yes, while Azelex is FDA-approved for acne, it is also commonly prescribed off-label to treat rosacea because it helps reduce redness and inflammation.
Comprehensive Drug Guide
How Does Azelex Work?
Azelex works by inhibiting the growth of Propionibacterium acnes, the bacteria that contribute to acne. It also normalizes the production of keratin, a protein that can block pores and lead to acne formation. Additionally, Azelex helps reduce inflammation, making it effective in treating the redness and swelling associated with acne and rosacea.
Common Dosages
- Topical cream: 20% azelaic acid
Typical Dosing
- For acne vulgaris: Apply a thin layer of Azelex cream to the affected areas of the face twice daily, once in the morning and once in the evening. Gently massage the cream into the skin until it is fully absorbed.
Typical Dosing
FDA Approved Indications
- Mild to moderate acne vulgaris
Who Shouldn't Take Azelex?
- Known hypersensitivity to azelaic acid or any component of the formulation.
- Use caution in individuals with hypopigmentation disorders (as it may cause skin lightening in some cases).
Advice From The Pharmacist
- Apply Azelex to clean, dry skin. Be sure to wash your hands before and after applying the cream.
- Avoid contact with the eyes, mouth, and mucous membranes. If accidental contact occurs, rinse thoroughly with water.
- You may experience mild stinging or burning when first applying Azelex, but this usually subsides with continued use.
- Use sunscreen during the day, as Azelex may increase sensitivity to sunlight.
Side Effects of Azelex
Common Side Effects
- Burning or stinging at the application site
- Itching or dryness
- Redness or peeling of the skin
Uncommon/Severe Side Effects
- Severe allergic reactions, such as rash, hives, or swelling of the face
- Skin discoloration, particularly in patients with darker skin tones
Risks and Warnings of Azelex
- Skin Irritation: Azelex may cause irritation, especially during the first few weeks of treatment. If irritation persists or worsens, consult your healthcare provider.
- Hypopigmentation: In rare cases, Azelex may cause lightening of the skin, particularly in individuals with darker skin. Monitor for any changes in skin color.
- Use in Pregnancy: Azelex is classified as Pregnancy Category B, meaning it should only be used during pregnancy if clearly needed and prescribed by a healthcare provider.
Interactions with Azelex
Common Drug Interactions
- Other Topical Medications: Using Azelex in combination with other topical treatments, such as retinoids or benzoyl peroxide, may increase skin irritation. Consult your healthcare provider before using multiple acne treatments.
- Cosmetics and Sunscreens: Choose non-comedogenic products that will not clog pores, and always use sunscreen to protect your skin from sun sensitivity while using Azelex.
Alternatives to Azelex
- Differin (adapalene): A topical retinoid available over-the-counter for treating acne.
- Benzoyl peroxide: A common over-the-counter acne treatment that works by reducing acne-causing bacteria and drying out the skin.
- Retin-A (tretinoin): A topical retinoid used for acne and other skin conditions, available by prescription.
- Salicylic acid: An over-the-counter acne treatment that helps exfoliate the skin and prevent clogged pores.
