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Atelvia
Atelvia (risedronate sodium delayed-release) is a bisphosphonate medication used to treat and prevent osteoporosis in postmenopausal women. It helps strengthen bones by inhibiting bone resorption, the process where bone cells break down bone tissue. By reducing bone loss, Atelvia helps improve bone density and reduce the risk of fractures, particularly in the hip and spine. It is a once-weekly treatment designed to improve adherence for patients with osteoporosis.
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Frequently Asked Questions
How long does it take for Atelvia to work?
Atelvia begins to work on the bones shortly after starting treatment, but it may take 6 months to a year for significant increases in bone density to be seen.
Can I take Atelvia with food?
Atelvia should be taken immediately after breakfast to reduce the risk of gastrointestinal upset. Avoid taking it on an empty stomach.
What should I do if I miss a dose of Atelvia?
If you miss a dose, take it the next morning after you remember. Then, resume your usual weekly schedule. Do not take two doses on the same day.
Can I take calcium or vitamin D with Atelvia?
Yes, you should maintain adequate intake of calcium and vitamin D while taking Atelvia. However, take calcium supplements at a different time of day to avoid interfering with the absorption of Atelvia.
Is Atelvia safe for long-term use?
Atelvia is generally considered safe for long-term use, but the risk of side effects such as osteonecrosis of the jaw and atypical femur fractures may increase with prolonged use. Regular monitoring by your healthcare provider is recommended.
Comprehensive Drug Guide
How Does Atelvia Work?
Atelvia works by inhibiting osteoclast activity, which are the cells responsible for breaking down bone tissue. This action helps to reduce bone loss (resorption) and increases bone mineral density (BMD). By slowing down the rate at which bones are broken down, Atelvia allows the bone-building cells, called osteoblasts, to strengthen the bone structure, reducing the risk of fractures.
Common Dosages
- Delayed-release tablets: 35 mg (to be taken once weekly)
Typical Dosing
- The recommended dose of Atelvia is 35 mg once a week.
- The tablet should be taken immediately after breakfast with at least 4 ounces of water. Avoid lying down for at least 30 minutes after taking the medication to prevent esophageal irritation.
Typical Dosing
FDA Approved Indications
- Treatment of osteoporosis in postmenopausal women
- Prevention of osteoporosis in postmenopausal women at risk for fractures
Who Shouldn't Take Atelvia?
- Hypocalcemia (low calcium levels in the blood)
- Esophageal abnormalities that delay emptying, such as strictures or achalasia
- Inability to remain upright for at least 30 minutes after taking the medication
- Known hypersensitivity to risedronate sodium or any other components of the drug
Advice From The Pharmacist
- Take Atelvia once a week after breakfast with a full glass of water. Avoid lying down for at least 30 minutes after taking the medication to reduce the risk of esophageal irritation.
- Do not take Atelvia with calcium supplements, antacids, or other medications that interfere with absorption. Take these products at a different time of day.
- Make sure to maintain adequate calcium and vitamin D intake during treatment to support bone health.
- If you miss a dose, take it the next morning after you remember, then resume your once-weekly schedule.
Side Effects of Atelvia
Common Side Effects
- Abdominal pain
- Diarrhea
- Dyspepsia (indigestion)
- Musculoskeletal pain
Uncommon/Severe Side Effects
- Esophageal irritation or ulcers
- Osteonecrosis of the jaw (ONJ), particularly after dental procedures
- Atypical femur fractures (rare but serious)
Risks and Warnings of Atelvia
- Esophageal irritation: Atelvia can cause irritation, inflammation, or ulceration of the esophagus. Patients should remain upright for at least 30 minutes after taking the medication and avoid lying down to minimize this risk.
- Osteonecrosis of the jaw (ONJ): This is a rare but serious condition that can occur, particularly in patients undergoing invasive dental procedures. Inform your dentist that you are taking Atelvia if you need dental surgery.
- Atypical femur fractures: Rare but serious fractures of the femur (thigh bone) have been associated with long-term bisphosphonate use. Patients should report any unusual thigh or groin pain.
Interactions with Atelvia
Common Drug Interactions
- Calcium supplements and antacids: These can interfere with the absorption of Atelvia. They should be taken at a different time of day, usually at least 30 minutes after the medication.
- Nonsteroidal anti-inflammatory drugs (NSAIDs): The combination of Atelvia with NSAIDs may increase the risk of gastrointestinal irritation.
- Aspirin: Concurrent use of aspirin may increase the risk of side effects, particularly gastrointestinal.
Alternatives to Atelvia
- Fosamax (alendronate): Another bisphosphonate used for the treatment and prevention of osteoporosis.
- Boniva (ibandronate): A once-monthly oral or intravenous bisphosphonate used for osteoporosis.
- Prolia (denosumab): A monoclonal antibody used to treat osteoporosis in postmenopausal women at high risk of fractures.
- Reclast (zoledronic acid): An intravenous bisphosphonate given once a year for osteoporosis treatment.
