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Arestin
Arestin (minocycline hydrochloride) is a locally applied antibiotic used to treat periodontitis, a serious gum infection that damages the soft tissue and bone that support the teeth. Arestin is administered as part of a periodontal treatment plan, often following scaling and root planing (deep cleaning) procedures. It is delivered directly into the periodontal pockets (spaces between the teeth and gums) to help reduce bacteria and promote gum healing.
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Frequently Asked Questions
How long does Arestin stay in the periodontal pocket?
Arestin microspheres release the antibiotic over 7-10 days. During this period, it actively reduces the bacterial load and inflammation in the treated areas.
Can I brush my teeth after receiving Arestin?
You should avoid brushing or flossing the treated areas for 10 days after Arestin is applied. You can continue brushing and flossing other areas of your mouth.
Is Arestin painful to apply?
Most patients experience little to no discomfort during the application of Arestin. Some mild gum irritation or tenderness may occur afterward, but it is usually temporary.
Does Arestin permanently cure periodontitis?
Arestin helps manage and control periodontitis, but ongoing maintenance, including good oral hygiene and regular dental visits, is essential to prevent the disease from progressing.
How soon can I eat after Arestin treatment?
It is generally recommended to avoid eating hard or sticky foods for the first few days after treatment. Soft foods are usually safe to eat shortly after the procedure. Follow your dentist's instructions for post-treatment care.
Comprehensive Drug Guide
How Does Arestin Work?
Arestin contains minocycline, an antibiotic that works by inhibiting the growth of bacteria responsible for causing periodontitis. Once applied into the periodontal pockets, Arestin releases minocycline over time, reducing the bacterial load and inflammation in the gums. This helps control the infection, allowing the gums to heal and reducing pocket depth.
Common Dosages
- Microspheres (minocycline hydrochloride): 1 mg per cartridge, applied by a healthcare provider
Typical Dosing
- Arestin is administered directly into the periodontal pockets by a dentist or periodontist following a scaling and root planing procedure. The microspheres are placed in the pocket, where they release minocycline over time.
- The number of sites treated will depend on the severity of the periodontitis, and additional treatments may be required based on the patient’s response.
Typical Dosing
FDA Approved Indications
- Treatment of periodontitis in conjunction with scaling and root planing procedures to reduce pocket depth and control the bacterial infection.
Who Shouldn't Take Arestin?
- Known hypersensitivity to tetracyclines (such as minocycline or doxycycline)
- Pregnancy, as tetracyclines can cause permanent tooth discoloration and developmental issues in the fetus
- Children under 8 years of age, due to the risk of permanent tooth discoloration
Advice From The Pharmacist
- Avoid brushing or flossing the treated areas for 10 days after Arestin is applied to allow the medication to work effectively.
- Continue practicing good oral hygiene for untreated areas, but be gentle around the treated sites to avoid disturbing the microspheres.
- If you experience any discomfort or signs of an allergic reaction, such as rash, itching, or swelling, contact your dentist or healthcare provider immediately.
- Follow-up visits are important to monitor the success of the treatment and to determine if additional treatments are needed.
Side Effects of Arestin
Common Side Effects
- Tooth sensitivity
- Gum discomfort or soreness
- Headache
- Mouth irritation
Uncommon/Severe Side Effects
- Allergic reactions (rash, itching, swelling)
- Severe gum irritation or infection
- Discoloration of the gums or teeth
Risks and Warnings of Arestin
- Allergic reactions: Patients allergic to tetracyclines should not use Arestin, as it can cause severe allergic reactions.
- Pregnancy risk: Tetracycline antibiotics like minocycline can cause permanent tooth discoloration in children and developmental issues during pregnancy. Arestin should not be used in pregnant women.
- Resistance: Prolonged or repeated use of antibiotics like Arestin can contribute to the development of antibiotic resistance. It should only be used as directed by your healthcare provider.
Interactions with Arestin
Common Drug Interactions
- Oral tetracyclines: If you are taking oral tetracyclines (such as doxycycline or minocycline), inform your dentist, as combining systemic and local antibiotics may increase the risk of side effects or bacterial resistance.
- Blood thinners: Tetracyclines can affect blood clotting, so if you are on blood thinners like warfarin, inform your healthcare provider.
- Oral contraceptives: Tetracyclines, including Arestin, may reduce the effectiveness of hormonal contraceptives. Use a backup method of contraception while using Arestin.
Alternatives to Arestin
- Periostat (doxycycline): An oral tetracycline antibiotic used to treat periodontitis and reduce pocket depth in conjunction with scaling and root planing.
- Chlorhexidine (PerioChip): A locally applied antibacterial chip placed into periodontal pockets to reduce bacterial growth.
- Scaling and root planing alone: In mild cases of periodontitis, non-surgical scaling and root planing without adjunctive antibiotics may be sufficient.
