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Anectine
Anectine, the brand name for succinylcholine, is a medication used to induce short-term muscle relaxation during medical procedures, including general anesthesia, endotracheal intubation, and mechanical ventilation. It belongs to the class of drugs known as neuromuscular blocking agents, which work by temporarily paralyzing the muscles. Anectine is a fast-acting medication, often used in emergency settings when rapid intubation is required or during certain surgeries that require muscle relaxation.
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Frequently Asked Questions
What should I do if I have a family history of malignant hyperthermia?
Inform your healthcare provider before receiving Anectine, as this condition is a contraindication for using succinylcholine. Your medical team can choose an alternative muscle relaxant.
How long does the effect of Anectine last?
The effects of Anectine typically last about 2-3 minutes, depending on the dose and individual response. However, additional doses may be administered during longer procedures.
Can I eat or drink before receiving Anectine?
Patients are usually advised to avoid food and drink prior to procedures requiring anesthesia or muscle relaxants to reduce the risk of aspiration. Follow the specific pre-procedure instructions given by your healthcare provider.
Does Anectine cause pain?
Anectine itself does not cause pain, but some patients may experience muscle stiffness or soreness after the effects wear off, especially in larger muscle groups.
Can Anectine affect my heart rate?
Yes, Anectine can cause changes in heart rate, either increasing or decreasing it. These effects are typically temporary but should be monitored by healthcare providers during the procedure.
Comprehensive Drug Guide
How Does Anectine Work?
Anectine works by mimicking the neurotransmitter acetylcholine, binding to receptors on the muscles and causing them to contract initially. It then prevents further stimulation by acetylcholine, leading to muscle paralysis. This temporary paralysis allows for procedures like intubation or surgery to occur without involuntary muscle movement. The effects of Anectine are fast-acting, typically lasting for a few minutes.
Common Dosages
- 20 mg/mL in multiple-dose vials
- 100 mg/mL in single-use vials
Typical Dosing
Based on the patient's weight and the procedure being performed
- For tracheal intubation, the usual dose is 0.6 mg/kg administered intravenously.
- For surgical procedures, the dose is typically 0.3-1.1 mg/kg, depending on the desired level of muscle relaxation.
Typical Dosing
FDA Approved Indications
- Facilitating tracheal intubation in surgical or emergency settings.
- Providing muscle relaxation during surgery or mechanical ventilation.
Who Shouldn't Take Anectine?
- History of malignant hyperthermia, a potentially fatal reaction to anesthesia.
- Known hypersensitivity or allergy to succinylcholine or its components.
- Patients with hyperkalemia (elevated potassium levels), as it can worsen the condition.
- Neuromuscular diseases (such as muscular dystrophy) or conditions that affect muscle control.
Advice From The Pharmacist
- Anectine should only be administered in controlled medical settings where equipment is available to manage airway, breathing, and cardiovascular function.
- Patients receiving Anectine will be closely monitored for potential side effects, including changes in heart rate, blood pressure, or breathing.
- After receiving Anectine, the effects will wear off within a few minutes, but follow-up care may be needed depending on the procedure.
Side Effects of Anectine
Common Side Effects
- Muscle pain or stiffness after the effects wear off.
- Bradycardia (slow heart rate) or tachycardia (fast heart rate).
- Increased saliva production or temporary difficulty in breathing (due to muscle paralysis).
Uncommon/Severe Side Effects
- Malignant hyperthermia, a life-threatening reaction to anesthesia characterized by a rapid rise in body temperature and severe muscle contractions.
- Hyperkalemia, a dangerous elevation of potassium levels in the blood.
- Prolonged muscle paralysis or difficulty breathing.
Risks and Warnings of Anectine
- Anectine carries the risk of malignant hyperthermia, especially in patients with a family history of this condition.
- Patients should inform their healthcare providers of any known risks.
- Additionally, succinylcholine can cause a dangerous increase in potassium levels, particularly in patients with certain neuromuscular conditions or burns.
- It is essential to use Anectine only in settings where emergency equipment and treatments are readily available.
Interactions with Anectine
Common Drug Interactions
- Other neuromuscular blocking agents, which may prolong muscle paralysis.
- Inhaled anesthetics (such as halothane), which increase the risk of malignant hyperthermia.
- Certain antibiotics (such as aminoglycosides), which can enhance the muscle-relaxing effects of succinylcholine.
- Diuretics and corticosteroids, which can affect potassium levels and increase the risk of side effects.
Alternatives to Anectine
- Rocuronium (a non-depolarizing muscle relaxant)
- Vecuronium (another non-depolarizing agent)
- Cisatracurium (used in settings requiring longer-lasting paralysis)
