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AndroGel Pump
AndroGel Pump is a topical testosterone replacement therapy used to treat adult males with conditions associated with a deficiency or absence of endogenous testosterone, such as hypogonadism. The pump formulation allows for easy application of the gel to the skin, providing a convenient method for delivering testosterone to the body. AndroGel helps increase testosterone levels, improving symptoms such as fatigue, decreased libido, and mood changes.
Drug Availability and Controlled Substance Status
AndroGel Pump is available in a 1.62% gel formulation, typically providing 20.25 mg of testosterone per pump actuation. It is a Schedule III controlled substance in the United States due to its potential for abuse and dependence. As a result, AndroGel is subject to strict prescribing regulations and monitoring.
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Frequently Asked Questions
Can AndroGel Pump be used by women?
No, AndroGel Pump is not intended for use by women and can be harmful if accidentally transferred to women, particularly those who are pregnant or breastfeeding.
How should AndroGel Pump be stored?
Store AndroGel Pump at room temperature, away from moisture and heat. Keep the pump out of reach of children and pets.
How long does it take for AndroGel Pump to work?
Patients may start to notice improvements in symptoms within a few weeks of starting AndroGel, but it may take up to 3 to 6 months to achieve full therapeutic effects.
What should I do if I miss a dose of AndroGel Pump?
If you miss a dose, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double the dose to make up for a missed one.
Comprehensive Drug Guide
How Does AndroGel Pump Work?
AndroGel Pump delivers testosterone transdermally (through the skin), where it is absorbed into the bloodstream. Testosterone is a key male hormone responsible for the development of male sexual characteristics, muscle mass, and bone density. By increasing testosterone levels, AndroGel helps alleviate the symptoms of low testosterone, restoring normal hormonal balance in men with hypogonadism.
Common Dosages
AndroGel Pump is available in the following dosage:
- 1.62% gel, with each pump delivering 20.25 mg of testosterone
Typical Dosing
The typical dosing for AndroGel Pump is:
Adults: Start with 40.5 mg (2 pump actuations) applied once daily in the morning to clean, dry, and intact skin on the shoulders and upper arms. The dosage may be adjusted based on serum testosterone levels, with a maximum dose of 81 mg per day (4 pump actuations).
Typical Dosing
FDA Approved Indications
AndroGel Pump is FDA-approved for the treatment of:
- Primary hypogonadism (congenital or acquired)
- Hypogonadotropic hypogonadism (congenital or acquired)
Off-Label Uses
There are no widely recognized off-label uses for AndroGel Pump.
Who Shouldn't Take AndroGel Pump?
AndroGel Pump should not be used in:
- Men with breast cancer or known or suspected prostate cancer
- Pregnant or breastfeeding women (due to potential harm to the fetus or infant)
- Individuals with hypersensitivity to testosterone or any of the components of the gel
Advice From The Pharmacist
Patients using AndroGel Pump should:
- Apply the gel to clean, dry skin on the shoulders or upper arms, and avoid application to the genital area.
- Wash hands thoroughly after application to prevent accidental transfer of testosterone to others.
- Allow the application site to dry before dressing, and avoid swimming or bathing for at least 2 hours after application.
- Regularly monitor testosterone levels and report any side effects, such as changes in mood, hair growth, or prostate symptoms, to their healthcare provider.
Side Effects of AndroGel Pump
Common Side Effects
Common side effects of AndroGel Pump include:
- Skin irritation at the application site (e.g., redness, itching)
- Increased red blood cell count (polycythemia)
- Acne
- Headache
Uncommon/Severe Side Effects
Serious side effects may include:
- Enlarged prostate (benign prostatic hyperplasia)
- Increased risk of prostate cancer
- Blood clots (deep vein thrombosis or pulmonary embolism)
- Cardiovascular events (e.g., heart attack, stroke)
Risks and Warnings of AndroGel Pump
Major risks and warnings associated with AndroGel Pump include:
- Secondary Exposure: There is a risk of secondary exposure to testosterone in women and children through direct contact with application sites. Careful handwashing and covering the application area are important to prevent this risk.
- Cardiovascular Risk: Testosterone therapy may increase the risk of cardiovascular events such as heart attack and stroke. Patients with cardiovascular disease or risk factors should be closely monitored.
- Prostate Health: Regular monitoring of prostate-specific antigen (PSA) levels is recommended, as testosterone therapy may exacerbate prostate cancer or benign prostatic hyperplasia.
Interactions with AndroGel Pump
Common Drug Interactions
AndroGel Pump may interact with:
- Insulin: Testosterone may affect blood glucose levels, potentially requiring adjustments in diabetes medications.
- Oral Anticoagulants (e.g., warfarin): Testosterone may increase the risk of bleeding, necessitating closer monitoring of INR levels.
- Corticosteroids: Concomitant use may increase the risk of fluid retention and edema.
Patients should inform their healthcare provider of all medications and supplements they are taking to avoid potential interactions.
Alternatives to AndroGel Pump
Alternative medications to AndroGel Pump include:
- Testosterone cypionate (injection): An injectable form of testosterone used for hormone replacement therapy.
- Testosterone patches (e.g., Androderm): A transdermal patch that delivers testosterone through the skin.
- Topical testosterone gel (e.g., Testim, Fortesta): Other gel formulations similar to AndroGel.
