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Aliskiren Fumarate
Aliskiren Fumarate is an antihypertensive medicine that falls under the class of direct renin inhibitors. It is commonly prescribed for reducing high blood pressure and preventing complications like heart attack and stroke. Some common side effects include headache, diarrhea, and fatigue, but oversights by your physician will ensure that the benefits of the drug override its downsides.
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Frequently Asked Questions
Can I just stop taking Aliskiren Fumarate after my blood pressure is controlled?
No, Aliskiren Fumarate is often part of a longterm management plan for controlling high blood pressure. Stopping it suddenly can cause your blood pressure to spike. Always follow the instructions provided by your healthcare provider for discontinuing any medication.
Can I take Aliskiren Fumarate if I have diabetes?
Yes, you can take Aliskiren Fumarate if you have diabetes. However, if you are combining this drug with ACE inhibitors or ARBs, there's a risk of adverse effects. Always consult your healthcare provider to understand the best treatment options for you.
Does Aliskiren Fumarate cause weight gain?
Weight gain is not a common side effect of Aliskiren Fumarate. However, if you experience unexplained weight gain, it would be best to consult your healthcare provider regarding the same.
I missed a dose of Aliskiren Fumarate, what should I do?
If you realize it is close to the time of your next dose, just skip the missed dose. If there's a considerable amount of time till your next dose, take your missed dose as soon as you remember. Avoid taking two doses at one time.
Comprehensive Drug Guide
How Does Aliskiren Fumarate Work?
Aliskiren Fumarate is a direct renin inhibitor that works by blocking the activity of renin, an enzyme that leads to the formation of a hormone known to constrict blood vessels and elevate blood pressure. With this interruption, Aliskiren helps in relaxing and widening your blood vessels, which makes it easier for your heart to pump blood around the body.
What is Aliskiren Fumarate Used For?
FDA indications: Aliskiren Fumarate is used for treating high blood pressure, reducing the chance of stroke, and preventing heart damage in people with chronic heart failure.
Offlabel uses: This drug is also used offlabel for certain kidney conditions associated with diabetes.
Common Dosages
Tablets: 150mg, 300mg
Typical Dosing
FDA Approved Indications
- For hypertension: 150mg to 300mg once daily. The dosage can be increased after 2 weeks if blood pressure control is inadequate.
Off-Label Uses
- For diabetic nephropathy: Dosage will be determined by your healthcare provider on a casebycase basis.
Who Shouldn't Take Aliskiren Fumarate?
- It is not suitable for those with severe kidney disease or for patients on dialysis.
- If you are pregnant or planning to become pregnant, the drug is not advised as it could harm the unborn baby, especially during the 2nd and 3rd trimesters.
- If you have a history of angioedema (swelling under the skin) related to other blood pressure medications.
- If you are allergic to Aliskiren.
Advice From The Pharmacist
- Always take Aliskiren Fumarate with a meal.
- Do not take it along with highfat foods as it could reduce absorption of the medicine.
- Keep yourself hydrated to avoid lightheadedness.
- Regularly check your blood pressure readings.
- Inform your healthcare provider if you are planning to become pregnant or get pregnant while on medication.
- Make sure to have regular blood work done to monitor kidney function.
Side Effects of Aliskiren Fumarate
Common Side Effects
- Diarrhea
- Cough
- Fatigue
- Dizziness, especially when standing up.
Uncommon/Severe Side Effects
- You might experience hypotension (very low blood pressure), especially if used with other blood pressure medications or diuretics.
- You might experience kidney issues, especially if you have a preexisting kidney condition.
- It might induce high levels of potassium in the blood, which can cause serious heart problems.
- If you experience any symptoms of angioedema like swelling of the face, lips, tongue, or throat, or difficulty breathing, go to the hospital right away.
Risks and Warnings of Aliskiren Fumarate
- Aliskiren Fumarate is not recommended for people with severe kidney issues or patients undergoing dialysis.
- Women who are pregnant or planning to become pregnant should avoid this medication as it can cause harm to the unborn baby.
- People with a susceptibility to angioedema (swelling under the skin caused by an allergic reaction) should exercise caution while taking Aliskiren Fumarate.
- If you have diabetes and are taking ARBs or ACE inhibitors with Aliskiren Fumarate, serious side effects can occur. Always consult your doctor before starting any new medication.
- In some rare cases, Aliskiren Fumarate may increase your potassium levels. This can cause complications if left unchecked. Regular blood tests would be necessary when on this medication.
Interactions with Aliskiren Fumarate
Common Drug Interactions
- Other antihypertensives
- Antidiabetic medications
- NSAIDs
- Diuretics
Alternatives to Aliskiren Fumarate
- Losartan
- Lisinopril
- Amlodipine
- Metoprolol
