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Adipex-P

Adipex-P, the brand name for phentermine, is a prescription medication used as a short-term treatment for obesity. It belongs to a class of drugs known as sympathomimetic amines, which are similar to amphetamines. Adipex-P is designed to suppress appetite, helping individuals with obesity or weight-related medical conditions lose weight when combined with diet, exercise, and behavioral changes. By reducing hunger and making it easier to stick to a calorie-controlled diet, Adipex-P helps manage weight loss in patients who are at increased health risk due to their weight.


Adipex-P is available by prescription only and can be found in most pharmacies. It is typically dispensed in tablet or capsule form. Adipex-P is classified as a Schedule IV controlled substance under the Controlled Substances Act due to its potential for abuse and dependence. This classification indicates that while it has a legitimate medical use, it also has the potential for misuse, and should be used under the strict supervision of a healthcare provider.


Adipex-P belongs to the formal drug class known as sympathomimetic amines, which are appetite suppressants. Informally, it may be referred to as a weight loss drug or diet pill. These classifications highlight its role in helping to control appetite and facilitate weight loss.



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Frequently Asked Questions

How long does it take for Adipex-P to start working?
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Adipex-P typically starts working within a few hours of taking the first dose, as it quickly reduces appetite and increases energy levels. However, the full effects on weight loss may take several weeks of consistent use in combination with diet and exercise.

Can I drink coffee while taking Adipex-P?
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It is advisable to limit caffeine intake while taking Adipex-P, as both caffeine and phentermine can increase heart rate and cause nervousness or jitteriness.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember, but avoid taking it late in the day to prevent insomnia. If it is close to your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one.

Can I take Adipex-P long-term?
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Adipex-P is intended for short-term use only, typically a few weeks. Long-term use is not recommended due to the risk of dependence and potential side effects. If you need further assistance with weight loss after completing your course of Adipex-P, discuss other options with your healthcare provider.

How should I store Adipex-P?
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Store Adipex-P at room temperature, away from moisture and heat, and keep it out of reach of children.

Can I stop taking Adipex-P abruptly?
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It is not recommended to stop taking Adipex-P suddenly, especially if you have been taking it for an extended period. Your healthcare provider may advise tapering the dose gradually to avoid withdrawal symptoms.

Comprehensive Drug Guide

How Does Adipex-P Work?

Adipex-P works by stimulating the central nervous system (CNS), including nerves and the brain, to increase heart rate and blood pressure while decreasing appetite. It achieves this by releasing certain chemicals in the brain that control appetite, leading to a reduced sensation of hunger. This makes it easier for patients to follow a calorie-restricted diet, promoting weight loss. The medication's effects are primarily short-term, intended to jump-start weight loss in conjunction with lifestyle changes.



Common Dosages

Adipex-P is typically available in the following strengths:

  • Tablets: 37.5 mg
  • Capsules: 37.5 mg

The dosage prescribed will depend on the patient's weight, medical condition, and response to treatment.


The typical dosing for Adipex-P is one tablet or capsule (37.5 mg) taken once daily, usually before breakfast or 1 to 2 hours after breakfast. Some patients may be prescribed a lower dose or a divided dose, depending on their individual needs and tolerance to the medication. It is important to follow the prescribed dosing schedule and not take the medication late in the day to avoid insomnia.



Typical Dosing

FDA Approved Indications

Adipex-P is FDA-approved for short-term use (a few weeks) as an adjunct to exercise, behavioral modification, and calorie reduction in the treatment of obesity. It is prescribed for patients with a body mass index (BMI) of 30 or higher, or for those with a BMI of 27 or higher who have other weight-related conditions such as hypertension, diabetes, or high cholesterol.

Off-Label Uses

There are no widely recognized off-label uses for Adipex-P, as its use is specifically focused on weight management under medical supervision.



Who Shouldn't Take Adipex-P?

Adipex-P should not be used in individuals who have:

  • A history of cardiovascular disease (e.g., heart disease, stroke, uncontrolled high blood pressure)
  • Hyperthyroidism (overactive thyroid)
  • Glaucoma
  • A history of drug abuse or dependence
  • Are currently pregnant, breastfeeding, or planning to become pregnant
  • A known hypersensitivity or allergic reaction to phentermine or other similar medications

It should also be used with caution in patients with other medical conditions, and it is important to discuss your full medical history with your healthcare provider.



Advice From The Pharmacist

When taking Adipex-P, it is important to follow your healthcare provider's instructions closely. Take the medication early in the day to avoid insomnia, and avoid drinking alcohol, as it can increase the risk of side effects. Stick to a balanced, calorie-controlled diet and incorporate regular exercise to maximize weight loss benefits. Be aware of the potential for dependence, and do not increase your dose or take it for longer than prescribed. If you experience any unusual side effects or symptoms, contact your healthcare provider immediately.



Side Effects of Adipex-P

Common Side Effects

Common side effects of Adipex-P include dry mouth, insomnia, dizziness, increased heart rate, and constipation. These side effects are generally mild and may lessen over time. More serious side effects, though rare, include chest pain, difficulty breathing, severe headache, and mood changes. If you experience any of these serious symptoms, seek medical attention immediately.

Risks and Warnings of Adipex-P

The major risks associated with Adipex-P include the potential for cardiovascular side effects, such as increased blood pressure and heart rate, as well as the risk of dependence and abuse. It is important to use this medication only as directed and for the short-term period prescribed. Patients with a history of heart disease or other serious health conditions should be closely monitored while taking Adipex-P. Additionally, abrupt discontinuation after prolonged use can lead to withdrawal symptoms, so tapering off the medication under medical supervision may be necessary.



Interactions with Adipex-P

Common Drug Interactions

Adipex-P can interact with other medications, including:

  • Monoamine oxidase inhibitors (MAOIs): These should not be taken with Adipex-P, as they can cause dangerous increases in blood pressure.
  • Other weight loss medications: Using multiple appetite suppressants can increase the risk of serious side effects.
  • Medications for depression or anxiety: Certain antidepressants and antianxiety medications can interact with Adipex-P and should be discussed with your healthcare provider.

Always inform your healthcare provider of all medications, supplements, and herbal products you are taking to avoid potential interactions.



Alternatives to Adipex-P

Alternative treatments for weight loss include other prescription medications such as orlistat (Xenical, Alli) or liraglutide (Saxenda), as well as non-pharmacological options like lifestyle changes, counseling, and bariatric surgery for eligible patients. Your healthcare provider can help determine the best treatment plan based on your specific needs and health goals.