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Adderall XR
Adderall XR is an extended-release formulation of a central nervous system stimulant medication containing amphetamine salts (amphetamine and dextroamphetamine). It is commonly prescribed to treat Attention Deficit Hyperactivity Disorder (ADHD) in children and adults. By increasing the levels of certain chemicals in the brain, Adderall XR helps improve focus, attention, and impulse control. It is also sometimes used to treat narcolepsy. The extended-release form allows for once-daily dosing, providing consistent symptom control throughout the day.
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Frequently Asked Questions
What should I do if I miss a dose of Adderall XR?
If you miss a dose, take it as soon as you remember, but avoid taking it in the afternoon or evening as it can interfere with sleep. Do not double up on doses to make up for a missed one.
Can I take Adderall XR with food?
Yes, Adderall XR can be taken with or without food. However, some patients find it easier on the stomach to take it with a meal or snack.
How long does Adderall XR last?
Adderall XR is designed to last up to 12 hours, providing all-day symptom relief for ADHD. The effects should gradually wear off toward the end of the day.
Can Adderall XR cause weight loss?
Yes, one of the side effects of Adderall XR is decreased appetite, which may lead to weight loss. It is important to monitor growth in children and to maintain a healthy diet while taking the medication.
Is Adderall XR addictive?
Adderall XR carries a risk of abuse and dependence, especially in individuals with a history of substance misuse. It should be used only as prescribed and monitored by your healthcare provider.
Comprehensive Drug Guide
How Does Adderall XR Work?
Adderall XR works by increasing the activity of neurotransmitters in the brain, specifically dopamine and norepinephrine, which are responsible for regulating attention, behavior, and impulse control. The extended-release formulation is designed to release these stimulant components gradually over the course of the day, providing more consistent symptom management compared to immediate-release formulations.
Common Dosages
- 5 mg, 10 mg, 15 mg, 20 mg, 25 mg, and 30 mg capsules.
- Your healthcare provider will prescribe the correct dosage based on your age, symptoms, and response to the medication.
Typical Dosing
For ADHD:
- Children 6-12 years old: The typical starting dose is 10 mg once daily in the morning. The dose may be adjusted by 5-10 mg increments weekly, depending on response. The maximum dose is 30 mg per day.
- Adolescents 13-17 years old: The typical starting dose is 10 mg once daily, with a maximum of 30 mg per day.
- Adults: The typical starting dose is 20 mg once daily in the morning, with adjustments as needed.
Adderall XR should be taken in the morning to avoid insomnia, as the stimulant effects can interfere with sleep.
Typical Dosing
FDA Approved Indications
- Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in children 6 years and older, adolescents, and adults.
- Treatment of narcolepsy (though this is more commonly treated with other stimulant medications).
Who Shouldn't Take Adderall XR?
- History of drug abuse or dependence, due to its potential for addiction.
- Known hypersensitivity to amphetamine or other ingredients in the medication.
- Severe heart problems (including arrhythmias, heart failure, or structural cardiac abnormalities).
- Moderate to severe high blood pressure (hypertension).
- Hyperthyroidism.
- Glaucoma
Advice From The Pharmacist
- Adderall XR should be taken once daily in the morning, with or without food.
- Avoid taking it later in the day, as it can cause insomnia.
- The capsule should be swallowed whole, but if swallowing is difficult, you can open the capsule and sprinkle the contents on a small amount of applesauce.
- Do not chew the beads.
- Avoid caffeine or other stimulants while taking Adderall XR, as they can increase side effects like jitteriness or elevated heart rate.
- It is important to monitor blood pressure and heart rate regularly while on this medication.
Side Effects of Adderall XR
Common Side Effects
- Decreased appetite or weight loss
- Dry mouth
- Insomnia or difficulty sleeping
- Nervousness or jitteriness
- Increased heart rate or blood pressure
- Stomach pain or nausea
Uncommon/Severe Side Effects
- Heart problems (chest pain, shortness of breath, or fainting)
- Behavioral changes, such as aggression or mood swings
- Seizures
- Signs of serotonin syndrome (confusion, agitation, rapid heart rate)
Risks and Warnings of Adderall XR
- Adderall XR carries a risk of addiction and dependence, especially in individuals with a history of substance abuse.
- Misuse of Adderall XR can lead to serious cardiovascular problems, including sudden death, stroke, or heart attack, particularly in individuals with pre-existing heart conditions.
- Adderall XR should be used with caution in individuals with a history of mental health disorders, such as bipolar disorder or anxiety, as it can worsen symptoms.
- Long-term use may require periodic “drug holidays” to evaluate the effectiveness of the medication and assess whether the individual still needs it.
Interactions with Adderall XR
Common Drug Interactions
- Monoamine oxidase inhibitors (MAOIs), which can cause dangerous increases in blood pressure.
- Antidepressants, particularly SSRIs, which can increase the risk of serotonin syndrome.
- Blood pressure medications, which may become less effective.
- Proton pump inhibitors (PPIs), which can affect how the medication is absorbed.
Alternatives to Adderall XR
- Vyvanse (lisdexamfetamine)
- Concerta (extended-release methylphenidate)
- Ritalin (methylphenidate)
- Strattera (atomoxetine) – a non-stimulant option
